Background: Hibiscus sabdariffa linnaeus (HSL) is a tropical plant with a high content of anthocyanin, traditionally found to have beneficial biological activities. This randomized, double-blind, placebo-controlled, and parallel trial was conducted to assess some renal and cardiovascular effects of supplementation with HSL in patients with diabetic nephropathy. Methods: The study protocol was c...

background: the most common clinical indication of aminoglycosides (ag) is the treatment of serious gram?negative infections.the aim of this study was to evaluate plausible effects of atorvastatin on the biomarkers of acute kidney injury (aki) in patients receiving amikacin. materials and methods: in this double?blinded randomized clinical trial, fifty patients (25 in each group) receiving amik...

background: contrast nephropathy will increase mortality up to 30% following angiographic procedures. adenosine is a crucial mediator of contrast-induced nephropathy. the purpose of this study was to investigate whether the adenosine antagonist theophylline reduces the incidence of cn after coronary angiography. methods: in this randomized, double-blind, placebo-controlled clinical trial study,...

A 72-year-old woman with CIDP was treated with IVIG. During the second day of treatment, the patient noticed an increase in abdominal girth and a decrease in urine output, without other symptoms. Laboratory findings included serum creatinine of 4.6mg/dl (407mmol/l) and blood urea nitrogen of 65mg/dl (23.2mmol/l). Urinalysis showed 2þ protein and many hyaline casts. A renal biopsy was done to de...

The aim of this study was to investigate the renal protective effect of icariin in 5/6 nephrectomized rats and the molecular mechanisms involved. Forty male Sprague-Dawley rats were randomly divided into 5 groups: sham-operated group, 5/6 nephrectomy model group, icariin groups (20 and 40 mg/kg), and benazepril group. After 12-weeks treatment, 24-h urine and serum were collected, and urine prot...

OBJECTIVES This study was conducted to quantitatively evaluate the recovery effects of methanolic fraction Angel's wings on gentamicin (GM)-induced nephrotoxicity. MATERIAL AND METHODS Renal injury was achieved by injecting 100 mg/kg, intraperitoneally of GM in normal saline. Extract were administrated intraperitoneally at doses 200 and 400 mg/kg. Blood samples were examined for serum creatin...

Objective: Effects of cotreatment with Urtica dioica (UD) methanolic leaf extract on gentamicin (GM)-induced acute kidney injury were evaluated in rats. Materials and Methods: Male Wistar rats (n=32) were separated into four groups. Gentamicin (100 mg/kg/day, IP) was injected for eight days with or without UD methanolic extract (200 mg/kg/day, gavage). Th...

Objective(s): Gentamicin belongs to the family of aminoglycoside antibiotics and is a preferred drug in developing countries because of its low cost, availability, and potent effects against bacterial. However, gentamicin can induce nephrotoxicity. In this research, hydroalcoholic extract of Rheum turkestanicum was used against gentamicin- induced nephrotoxicity. Rheum turkestanicum is used aga...

hemiscorpius lepturus is the most dangerous scorpion species, endemic in khuzestan province and other southwestern areas of iran, causing morbidity and mortality in children and adults. the efficacy of the antivenom for reversal of manifestation caused by venom of this scorpion is a controversial issue. in the present work, h. lepturus venom (1500 µg/kg) was subcutaneously injected into two ...