A frontal lobe syndrome has previously been reported in adults treated with selective serotonin reuptake inhibitors (SSRIs), but not in children. Five typical cases of apathy and lack of motivation, one accompanied by disinhibition, are described in a child and four adolescents. Symptoms were dose related and reversible. The subtlety of symptoms, lack of insight in patients, disabling effects, ...

Hyponatremia complicates 1% of hospital admissions and can be associated with serious central nervous system effects. We report a case of a 38year-old woman with hyponatremia resulting in seizures and coma. Medications are one of many causes of hyponatremia. This case emphasizes the need to consider selective serotonin reuptake inhibitors (SSRIs) as a potential source of hyponatremia in all age...

BACKGROUND Use of antidepressants during pregnancy has been associated with a low Apgar score in infants but a contribution from the underlying depressive disorder might influence this association. AIMS To estimate the effects of maternal depression and use of antidepressants during pregnancy on low Apgar scores (<7) 5 min after birth. METHOD Register study on all pregnant women in Denmark ...

Chronic administration of selective serotonin reuptake inhibitors (SSRIs), which up-regulates central serotonin (5-HT) system function, enhances adult hippocampal neurogenesis. However, the relationship between central 5-HT system and adult neurogenesis has not fully been understood. Here, we report that lowering 5-HT level in adulthood is also able to enhance adult hippocampal neurogenesis. We...

Clinical impact ratings Mental health wwwwwwq Psychiatry wwwwwwq Paediatrics wwwwwwq GP/FP/Primary care wwwwwwq . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Q Are selective serotonin reupt...

QUESTION I have read that fluoxetine is the drug of choice for treating depression during pregnancy. One of my patients, who did not respond to the "old" selective serotonin reuptake inhibitors, is doing well on venlafaxine and is now 6 weeks pregnant. What advice should I give her? ANSWER Fluoxetine is recommended because to date it has the most evidence of its safety. It is important that w...

AIM To investigate the relationship between selective serotonin reuptake inhibitor (SSRI) use and the subsequent development of irritable bowel syndrome (IBS). METHODS This retrospective, observational, population-based cohort study collected data from Taiwan's National Health Insurance Research Database. A total of 19653 patients newly using SSRIs and 78612 patients not using SSRIs, matched ...

Study selection Studies were eligible if they were randomised, doubleblind parallel trials of at least 8 weeks duration; used the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) to assess the efficacy of clomipramine or selective serotonin reuptake inhibitors for obsessive-compulsive disorder, and included point estimates, standard deviations or calculable data. The authors included 25 trials.

Depression is a polygenic and highly complex psychiatric disorder that is currently a major burden on society. Depression is highly heterogeneous in presentation and frequently exhibits high comorbidity with other psychiatric and somatic disorders. Commonly used treatments, such as selective serotonin reuptake inhibitors (SSRIs), are not ideal since only a subset of patients achieve remission. ...

QUESTION Functional gastrointestinal disorders (FGIDs) are complex conditions I see in some of my pediatric patients. The indications for antidepressants such as selective serotonin reuptake inhibitors (SSRIs) do not include treatment of FGIDs; however, some children are prescribed SSRIs for this condition. Are antidepressants effective and safe to use for treating FGIDs in children and adolesc...