The need for a multiple-target compound selectivity programme led to the establishment of a single robotic system that produces a compound's serial dilution and its distribution to multiple replicate assay plates. A Genesis RSP 150 integrated into a Zymate Laboratory Automation System XP produced the serial dilutions, and the subsequent replicate assay plates were produced quickly and accuratel...

This paper describes a fully automated droplet-based microfluidic device for on-demand serial dilution that is capable of achieving a dilution ratio of >6000 (concentration ranges from 1 mM to 160nM) over 35 nanoliter-scale droplets. This serial diluter can be applied to high throughput and label-free kinetic assays by integrating with our previously developed on-demand droplet-based microfluid...

1. The theory of the serial dilution method of titration of bacterio-phage has been worked out on the basis of the simple particulate hypothesis. 2. It has been shown that, if the dilution constant is .1, only about 60 per cent of parallel runs on the same solution should give the same end-point, the average being taken over a great number of titrations of each of a great variety of solutions. ...

An Improved Thermal Dilution Method for Measuring Jugular Venous Flow • The local thermal dilution method of performing serial bilateral measurements of internal jugular venous flow is significantly improved by injecting a bolus of saline rather than by using a continuous injection of saline. New thermistor catheter designs maintain the proper separation between the sites of injection and of sa...

The resting output of the normal heart has been investigated by many workers (Krogh and Lindhard, 1912; Christiansen et al., 1914; Stewart, 1921; Grollman, 1928; Hamilton et al., 1932; Nylin, 1933; Berseus, 1943; McMichael and Sharpey-Shafer, 1944; Cournand et al., 1945; Stead et al., 1945; Werko, 1947; Chapman et al., 1950; Doyle, et al., 1953; Donald et al., 1955; Goodyer et al., 1960; Reeves...

The Evolution of the Horticulturist: PROFESSOR Scientific Apparatus and Laboratory Methods: T. H. MCHATTON ................................ 469 A Critique of the Serial Dilution Method f r Quantitative Determination of Bacteriophage: DR. The George Eastman Research Laboratories for A. P. KRUEGER. A Simple Method of Rearing and Physics and Chemistry: DR. KARL T. COMPTON 472 Mounting Hookworm Lar...

T HE method for measuring cardiac output based on the "dye dilution" principle of Stewart and Hamilton" 2 involves the injection of a known amount of colored substance into a vein and collection of serial samples of blood from an artery for determination of the concentration of dye. Other substances have been used for injection, such as salt solution and radioactive cells.3' 4 The validity of t...