SUMMARY: TWO PREPARATIONS ARE AVAILABLE FOR PLATELET TRANSFUSION: single-donor apheresis platelet concentrates (APC) and pooled platelet concentrates (PPC) prepared from 4-6 whole blood units. Clear advantages of APC over PPC are a markedly reduced donor exposure of recipients, and easier logistics when attempting a complete supply with ABO-identical and Rh-compatible platelet concentrates. Reg...

The coronavirus disease 2019 (COVID-19) pandemic continues to cause significant morbidity and mortality worldwide. This study aims identify specific lab markers, complications, treatments that may be associated with increased in COVID-19 patients. is retrospective nature; it included 217 positive patients who were admitted a ProMedica Health System hospital Northwest Ohio, United States, betwee...

• Bacterial sepsis from contaminated platelet transfusions continues to occur despite recent interventions; additional measures are needed. • STR to platelet transfusion is frequently not recognized or reported; use of recent AABB criteria showed highest diagnostic sensitivity. Septic transfusion reactions (STRs) resulting from transfusion of bacterially contaminated platelets are a major hazar...

Septic shock, occurring in about 1% of neonates hospitalized in neonatal intensive care unit (NICU), is a major cause of death in the neonatal period. In the 1980s and 90s, exchange transfusion (ET) was reported by some authors to be effective in the treatment of neonatal sepsis and septic shock. The main aim of this retrospective study was to compare the mortality rate of neonates with septic ...

Bacterial contamination of blood components is a persistent but often overlooked problem in transfusion medicine. Although public attention has focused on transfusion-transmitted viral infection, improved methods of screening through donor questioning and testing have greatly reduced the transmission of hepatitis viruses and retroviruses. Given the reduction of viral transmission via allogeneic...

Sepsis is one of the major causes of death worldwide, and is the host response to infection which renders our organs malfunctioning. Insufficient tissue perfusion and oxygen delivery have been implicated in the pathogenesis of sepsis-related organ dysfunction, making transfusion of packed red blood cells (pRBCs) a reasonable treatment modality. However, clinical trials have generated controvers...