introduction: dyspepsia, gastroesophageal reflux disease (gerd) and irritable bowel syndrome (ibs) are the most common gastrointestinal diseases. their prevalence is 18-30%, 25-30% and 10-15% in western communities and 8-14%, 3-7% and 3-5% in eastern countries, respectively. there is no adequate data about their prevalence in our country. the aim of this study is to determine the prevalence of ...

INTRODUCTION Toll-like receptors (TLRs) play an important role in the recognition of microbial products and in host defense against infection. However, the massive release of inflammatory mediators into the bloodstream following TLR activation following sepsis is thought to contribute to disease pathogenesis. METHODS Here, we evaluated the effects of preventive or therapeutic administration o...

Primary hemophagocytic lymphohistiocytosis (HLH) is a rare fulminant genetic disease with uncontrolled immune activation and multiorgan involvement. It quite in neonates but high index of suspicion needed as the condition will present like sepsis associated mortality. Persistent fever prominent clinical feature. Genetic diagnosis essential autosomal recessive familial types. Here, we report fou...

Sepsis is an imbalanced response to infection that leads life-threatening organ dysfunction. Although increasing number of anti-inflammatory drugs are available, the options for treating sepsis remain limited. Therefore, it imperative understand pathogenesis and pathophysiology develop novel therapeutic targets treat this state. The Nod-like receptor family pyrin domain-containing 3 (NLRP3) inf...

INTRODUCTION Kikuchi-Fujimoto disease, is usually a benign self-limiting disease which typically affects young females under the age of 30 years and resolves without treatment within six months. However, when it occurs in the context of connective tissue disease, particularly systemic lupus erythematosus (SLE), it is usually associated with a flare-up of the patient's symptoms, requiring treatm...

BACKGROUND Diabetes is associated with chronic inflammation and activation of the vascular endothelium and the coagulation system, which in a more acute manner are also observed in sepsis. Insulin and metformin exert immune modulatory effects. In this study, we aimed to determine the association of diabetes and preadmission insulin and metformin use with sepsis outcome and host response. METH...

Leptospirosis is one of the most relevant zoonosis worldwide and a potentially life-threatening infectious disease. While it is frequent in tropic regions, it is uncommon in European industrialized countries. Angiopoietin-2 (Angpt-2) and asymmetric and symmetric dimethylarginine (ADMA and SDMA) are markers of endothelial activation and systemic inflammation. These parameters have been studied r...

In postoperative wound infections due to Escherichia coli, 59%o of the sepsis was caused by ten 0-serotypes. For each serotype, except 06, the frequency of sepsis mirrors the frequency of carriage. Endogenous wound infection: evidence was presented but not discussed. Eleven patients had wound infections due to serotype 06, five were carriers of this serotype at the time of operation. Serotype 0...

Introduction Sepsis lacks a reliable measure of disease activity [1,2]. Therefore, it remains unclear how to monitor the response to treatment. Little is known about changes in vital signs during sepsis resuscitation and biomarkers for disease activity are not available to evaluate effects of treatment in sepsis patients at the bedside [2,3]. Trends in vital signs and biomarker levels during re...