Some anesthetic agents administered during general anesthesia can cause heart rhythm disorders, mainly associated with autonomic imbalance. Off-target cardiac sodium channel blockade is considered the canonical mechanism behind cardiotoxicity. Lidocaine, most common local anesthetic, produces a transient loss of sensory, motor, and function when drug injected or applied close to neural tissues;...

background postoperative residual blockade, longer duration of action for neuromuscular blockade, and slower recovery were relatively common in elderly patients. objectives we aimed to investigate the safety of train-of-four ratio and clinical tests in the assessment of patient recovery, and to determine the effects of the rocuronium, vecuronium, and cisatracurium on intubation, extubation and ...

BACKGROUND The effects of volume and baricity of spinal bupivacaine on block onset, height, duration, and hemodynamics were studied. METHODS Ninety patients undergoing endoscopic urologic procedures were randomized to receive 10 mg of intrathecal bupivacaine at L2-L3 level in sitting position. In the operating room, commercial products were diluted as needed with NaCl 0.9% to obtain isobaric ...

Peripheral nerve blocks are becoming increasingly popular for perioperative use as anesthetics and analgesics in small animals. This prospective study was performed to investigate the duration of motor and sensory blockade following use of bupivacaine for ultrasound-guided femoral and sciatic nerve blocks in dogs and to measure the plasma concentrations of bupivacaine that result from these pro...

BACKGROUND Anesthesia induction in patients with current substance abuse can be a challenge for anesthesiologists. OBJECTIVES This study aimed to evaluate the effect of adding Sufentanil to Bupivacaine on duration of brachial plexus nerve block. PATIENTS AND METHODS One hundred and twenty patients with (Groups C and D) and without (Groups A and B) a history of opium abuse (60 in each group)...

Background and Aim: To study compare the hemodynamic stability duration of analgesia in spinal anaesthesia among bolus versus lower fractional doses bupivacaine arachnoid block for patients undergoing abdominal surgeries specifically urologic, pelvic, limb surgeries. Methods: Interventional Randomized Comparative case-control done 70 participants to with under subarachnoid Results: sum up, we f...

The use of high concentration (0.2-0.25%) of local anaesthetic in the past to maintain labour analgesia has been superseded by the use of low concentration (0.0625-0.125%) of either bupivacaine or ropicavaine. Ropicavaine is a new local anaesthetic that has preferential sensory blockade and less motor blockade compared to bupivacaine. Combined with low doses of opioid (such as fentanyl), the sa...

The construction of spinal sensory-motor circuits involves the selection of appropriate synaptic partners and the allocation of precise synaptic input densities. Many aspects of spinal sensory-motor selectivity appear to be preserved when peripheral sensory activation is blocked, which has led to a view that sensory-motor circuits are assembled in an activity-independent manner. Yet it remains ...

No significant differences observed in the onset of sensory block (5.05min and 5.4min in group B and R respectively, P>0.05).The mean motor blockade score, time to achieve complete blockade and time to grade I motor recovery was significantly longer in group B (2.3, 22.5 and 79.5 minutes respectively) as compared to group R (1.5, 18.3 and 66.3 minutes respectively, P<0.05). Respiratory distress...

conclusions the addition of magnesium sulfate to lidocaine increased the duration of motor and sensory axillary block in the upper extremities during surgeries when compared to the use of lidocaine alone. results a total of 60 patients were included in the study with 30 patients having received lidocaine plus magnesium and the other 30 patients having received lidocaine plus normal saline. the ...