Over the last 50 years, compelling evidence has accumulated on the beneficial role of selenium in human health. In the present study, different proteins were evaluated as reducing agents for the eco-friendly synthesis of selenium nanoparticles from an aqueous solution of sodium selenite. This method is a simple, low cost green synthesis alternative to chemical synthesis. The high conversion of ...

Small ubiquitin-like modifier (SUMO) modification is an important post-translational protein modification that can be reversed by SUMO-specific proteases (SENPs); however, the physiological function of SENPs remains largely unexplored, and little is known about the regulation of SENPs themselves. As one of the crucial members of the SUMO system, SENP3 is essential for rRNA processing and cell p...

BACKGROUND Selenium is well documented to inhibit cancer at higher doses; however, the mechanism behind this inhibition varies widely depending on the cell type and selenium species. Previously, we have demonstrated that Bacillus licheniformis JS2 derived biogenic selenium nanoparticles (SeNPs) induce non-apoptotic cell death in prostate adenocarcinoma cell line, PC-3, at a minimal concentratio...

Small ubiquitin-related modifiers (SUMOs) are conjugated to proteins to regulate a variety of cellular processes. SENPs are cysteine proteases with a catalytic center located within a channel between two subdomains that catalyzes SUMO C-terminal cleavage for processing of SUMO precursors and de-SUMOylation of target proteins. The β-grasp domain of SUMOs binds to an exosite cleft, and allosteric...

Bacterial symbionts can promote insecticide resistance in their hosts by isolating and degrading insecticidal compounds or altering the expression of host genes. Although Wolbachia, a common endosymbiont arthropods, typically does not influence resistance, there are cases increased decreased susceptibility. Due to restrictions applying conventional insecticides stored product setting, studies o...

Ubiquitin-like protein/sentrin-specific proteases (Ulp/SENPs) mediate both processing and deconjugation of small ubiquitin-like modifier proteins (SUMOs). Here, we show that Ulp/SENP family members SENP3 and SENP5 localize within the granular component of the nucleolus, a subnucleolar compartment that contains B23/nucleophosmin. B23/nucleophosmin is an abundant shuttling phosphoprotein, which p...

Owing to their excellent bioavailability, high bioactivity, and low toxicity, selenium nanoparticles (SeNPs) are emerging nanomaterials. In this study, SeNPs with a size of ∼41.8 nm were synthesised by γ-irradiation using oligochitosan (OCS) as the stabiliser. As-synthesized SeNPs/OCS characterised UV-Vis spectroscopy, transmission electron microscopy, energy-dispersive X-ray (EDX) analysis. Re...

Selenium nanoparticles (SeNPs) have been demonstrated potential for use in diseases associated with oxidative stress. Functionalized SeNPs lower toxicity and higher biocompatibility could bring better therapeutic activity clinical application value. Herein, this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized...

Abstract The fish-borne zoonotic bacteria may pose a risk to humans; nanobiotechnological techniques could serve as effective solutions for fighting them. direct phycosynthesis of metals’ nanoparticles (NPs), silver (AgNPs), and selenium (SeNPs) using Corallina officinalis extract (CoE) was achieved. construction nanocomposites (NCs) from phycosynthesized NPs nano-chitosan (NCht) also accomplis...