Global inactivation of the metalloproteinase ADAM17 during mouse development results in perinatal lethality and abnormalities of the heart, including late embryonic cardiomegaly and thickened semilunar and atrioventricular valves. These defects have been attributed in part to a lack of ADAM17-mediated processing of HB-EGF, as absence of soluble HB-EGF results in similar phenotypes. Because valv...

Statement of problem: One of the main goals in periodontal therapy is the correction of recession defects; therefore the efficacy and predictability of the various techniques are important considerations for clinicians. Purpose: The purpose of this pilot study was to compare the outcomes of gingival recession therapy using the semilunar coronally repositioned flap (SCRF) alone and in conjunctio...

The outflow tract (OFT) provides the structural components forming the ventriculoarterial connection. The prevailing concept that this junction "rotates" to acquire its definitive topography also requires a concept of "counterrotation" and is difficult to reconcile with cell-marking studies. Rats between 10 embryonic days (EDs) and 2 postnatal days were stained immunohistochemically and by in s...

The clinical, hemodynamic, and pathologic findings in two newborn infants with persistent truncus arteriosus and stenosis of the truncal valve are described. In one case the anatomic features of the basic condition were classic, with a dysplastic semilunar valve which was mainly stenotic and also incompetent, while in the other the truncus arteriosus arose exclusively from the right ventricle a...

BACKGROUND Gingival recession (GR) is one of the most common esthetic and functional concerns associated with periodontal disease. A variety of surgical procedures has been introduced to the field of cosmetic periodontology for the treatment of GR. AIM To evaluate and compare the clinical outcome of semilunar coronally advanced flap (SCAF) with and without button technique in the treatment of...

OBJECTIVE Tooth loss is a common problem and since current tooth replacement methods cannot counter balance with biological tooth structures, regenerating natural tooth structures has become an ideal goal. A challenging problem in tooth regeneration is to find a proper clinically feasible cell to seed.This study was designed to investigate the odontogenic potential of human bone marrow mesenchy...