QSAR approaches, including recent advances in 3D-QSAR, are advantageous during the lead optimization phase of drug discovery and complementary with bioinformatics and growing data accessibility. Hints for future QSAR practitioners are also offered.

Background and Objective: Temporal lobe epilepsy (TLE) is a chronic neurological disorder with spontaneous recurrent seizures and abnormal intracranial waves. Since the role of oxidative stress in the occurrence of epilepsy is inevitable, it seems that the use of antioxidants can prevent some of the complications resulting from this disease. This study was designed to assess the protective effe...

Fundamental change seems increasingly inevitable, but at the same time increasingly unimaginable. A variety of public private partnering arrangements and innovative financing mechanisms has begun to change the neglected disease landscape over the last decade. How significant are these public-private partnership (PPP) arrangements? Are these players likely to endure? Do they deserve the continue...