نتایج جستجو برای: sebum
تعداد نتایج: 628 فیلتر نتایج به سال:
Sebum provides vital cutaneous functions including moisture retention and defense against the external environment, pathogens. Despite well-defined homeostatic of sebum in fortifying skin barrier, role microbiota-immune system axis regulation remains unclear. We have recently shown that keratinocyte-derived cytokine thymic stromal lymphopoietin (TSLP) promotes secretion through T cell stimulati...
Background: Zileuton, a 5-lipoxygenase inhibitor, reduces the number of infl ammatory lesions in moderate acne and inhibits the synthesis of sebaceous lipids. Objective: To detect whether zileuton directly reduces sebum synthesis. Methods: A 40-year-old female with mild disseminated sebaceous gland hyperplasia and seborrhea was treated with zileuton 4 ! 600 mg/day over 2 weeks, was followed-up ...
The recent work of Kligman and Shelley (1) does much to advance our concepts of the physiology of sebaccous secretion. This paper presents several experimental observations that intend to further modify these concepts. The composition of scbum has been thoroughly explored. From an examination of its approximate composition, one would expect sebum to emulsify water as the internal phase of a wat...
Acne vulgaris is a skin disorder of the sebaceous follicles, involving hyperkeratinization and perifollicular inflammation. Matrix metalloproteinases (MMP) have a predominant role in inflammatory matrix remodeling and hyperproliferative skin disorders. We investigated the expression of MMP and tissue inhibitors of MMP (TIMP) in facial sebum specimens from acne patients, before and after treatme...
BACKGROUND Scalp seborrheic dermatitis is a chronic type of inflammatory dermatosis that is associated with sebum secretion and proliferation of Malassezia species. Ketoconazole or zinc-pyrithione shampoos are common treatments for scalp seborrheic dermatitis. However, shampoos comprising different compounds are required to provide patients with a wider range of treatment options. OBJECTIVE T...
Seborrheic dermatitis is a common chronic inflammatory skin condition, characterized by scaling and poorly defined erythematous patches. It may be associated with pruritus, and it primarily affects sebum-rich areas, such as the scalp, face, upper chest, and back. Although its pathogenesis is not completely understood, some postulate that the condition results from colonization of the skin of af...
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