Melanoacanthoma is a rare benign mixed tumor of both keratinocytes and melanocytes. Although some authors said that it is a rare variant of seborrheic keratosis, it has clinical and histological features distinct from seborrheic keratosis. It has large dendritic melanin-laden melanocytes throughout all levels of epidermis showing a disruption of melanin transfer from the melanocytes to neighbor...

Seborrheic keratosis is the most common benign tumor of epidermis. Rarely develops in perineal area and quite rarely large. For Leser-Trelat syndrome these tumors a marker malignant disease even before symptoms are appeared, as well manifestation paraneoplastic process. In our case report, giant perianal seborrheic keratoma was reason for clinical examination patient stomach cancer detected. As...

A 58 year old man was referred to suegery clinic due to dyspnea and left sided chest wall pain for three months duration.during the last 18 months some monomorph disseminated hyperkeratotic skin lesions appeared on his face and trunk.after worlup and evaluation of the patient,he underwent thoracotomy with indication of presence of a mass in the left lung.the operative finding was a huge solid r...

background: seborrheic keratoses (sk) are common, benign and often multiple skin tumors with disputed etiology. a follicular origin, late onset nevoid disturbance or local arrest in maturation of keratinocytes have been proposed. human papilloma virus (hpv) has been detected in a small number of cases, particularly those from the genital region. objectives: the aim of our study was to evaluate ...

We describe a case of melanoma with the presence of comedo-like openings at dermoscopy. These structures, typical of seborrheic keratosis, represent an uncommon finding in melanoma. We emphasize the importance of searching for specific dermoscopic criteria for melanocytic lesions during the examination of a pigmented lesion, despite possible observations of characteristic structures of non-mela...

Commentary | Dermatol Pract Concept 2013;4(1):5 43 Have we really concluded what a large cell acanthoma is? Is it a distinct entity, a solar lentigo, a subtype of seborrheic keratosis, or an HPV-induced acanthoma? In 1970, large cell acanthoma (LCA) was first described by Pinkus, as a sharply demarcated, hyperkeratotic patch, often on sun-exposed skin, characterized by extraordinarily large cel...