_______________________________________________________________________________________ Abstract Selection accuracy for resistance to mastitis may be increased by combining somatic cell score (SCS) and udder type into an udder health index, using genetic parameter estimates among them. A multi-trait animal model was used to estimate genetic parameters among lactation average SCS and udder type ...

Stratum corneum lipids play an important role in the barrier function of the skin. An in vitro permeation model consisting of synthetic lipids has previously been developed to replace human stratum corneum (SC) in permeation studies. This model is referred to as the stratum corneum substitute (SCS). In order to improve its reproducibility and to increase the efficiency in preparing the SCS, two...

Insulators are defined as a class of regulatory elements that delimit independent transcriptional domains within eukaryotic genomes. The first insulators to be identified were scs and scs', which flank the domain including two heat shock 70 genes. Zw5 and BEAF bind to scs and scs', respectively, and are responsible for the interaction between these insulators. Using the regulatory regions of ye...

PURPOSE To evaluate the neuroprotective effect of intravitreal injections of neurotrophic factors secreting mesenchymal stem cells (NTF-SCs) on the survival of retinal ganglion cells (RGCs) in rat eyes after optic nerve transection (ONT). METHODS Rat and human bone marrow-derived mesenchymal stem cells (MSCs) were induced to secrete high levels of NTF. The neuroprotective effect from intravit...

OBJECTIVES Healthcare policy makers and payers require cost-effectiveness evidence to inform their treatment funding decisions. Thus, in 2008, the United Kingdom's National Institute of Health and Clinical Excellence analyzed the cost effectiveness of spinal cord stimulation (SCS) compared with conventional medical management (CMM) and with reoperation and recommended approval of SCS in selecte...

Compound action potential (CAP) of spinal cord represents valuable properties of neural fibers including excitability, rate of myelination and membrane integrity. These properties are measured using amplitude, latency and area under curve of CAPs recorded from spinal cord. Here, the isolated spinal cord was set in a double sucrose gap (DSG) chamber and its response to intracellular stimulation ...

The ionic model of the ventricular myocyte developed by Luo and Rudy ( Circ. Res. 74: 1071-1096, 1994) was used to investigate potential mechanisms of the slow changes in stress (SCS) that follow step changes in muscle length. A step change in myofilament sensitivity alone caused an immediate increase in active tension, but no SCS. The effects of additional step changes in the parameters of sar...

Skeletal muscle satellite cells (SCs) are Pax7(+) myogenic stem cells that reside between the basal lamina and the plasmalemma of the myofiber. In mature muscles, SCs are typically quiescent, but can be activated in response to muscle injury. Depending on the magnitude of tissue trauma, SCs may divide minimally to repair subtle damage within individual myofibers or produce a larger progeny pool...

Gu et al. use ultra-high resolution ocular coherence tomography (UHR-OCT) in the guinea pig eye model to evaluate suprachoroidal drug delivery using 10to 20-lL injections of either saline, indocyanine green (ICG), or triamcinolone acetate (TA). The authors have an elegantly designed study that measures the cross-sectional area of the suprachoroidal space (SCS) using these various injections at ...

Chronic neuropathic pain caused by injury to or disease in the nervous system is relatively common and results in major suffering, poor quality of life and incapacity. Such pain is a therapeutic challenge because a considerable portion of the patients fails to benefit from pharmacotherapy. Therefore, there is a need for alternative treatment modalities. Spinal cord stimulation (SCS) has proven ...