The tyrosine nitration of proteins has been observed in diverse inflammatory conditions and has been linked to the presence of reactive nitrogen species. From many in vitro experiments, it is apparent that tyrosine nitration may alter the function of proteins. A limited number of experiments under in vivo conditions also demonstrate that protein nitration is associated with altered cellular pro...

Type I polyketide synthases (PKSs) are complexes of large, multimodular enzymes that catalyse biosynthesis of polyketide compounds via repetitive reaction sequences, during which each step is catalysed by a separate enzymic domain. Many type I PKSs, and also non-ribosomal peptide synthetase clusters, contain additional thioesterase genes located adjacent to PKS genes. These are discrete protein...

SCOT-HEART (Scottish COmputed Tomography of the HEART) and PROMISE (PROspective Multicenter Imaging Study for Evaluation of chest pain) represent the 2 largest and most comprehensive cardiovascular imaging outcome trials in patients with stable chest pain and provide significant insights into patient diagnosis, management, and outcomes. These trials are particularly timely, given the well-recog...

Organizations invest in information technology (IT) looking for positive results that can only be produced if the technology is effectively used by individuals. The Technology Acceptance Model (TAM) applies a simple and quantitative model to predict intention of use, but it has difficulties to keep its explanatory power when analyzing implementation in mandatory settings (which are usual in bus...

This paper considers how planning authorities can achieve urban design ambitions in the context of deepening neoliberalism and fiscal austerity. Based upon a case study West Dunbartonshire, Scot...

In designing and building tutorial dialogue systems it is important not only to understand the tactics employed by human tutors but also to understand how tutors decide when to use various tactics. We argue that these decisions are based not only on student problem-solving steps and the content of student utterances, but also on the meta-communicative information conveyed through spoken utteran...

Analyzing the literature of computing history we can establish that computing stories of different epochs are concerned with an array of problem areas, thus the authors of the accounts posed various questions – from the misunderstood inventions and forgotten genius to the community revaluation role of the Internet in the post-modern society. J. V. Atanasoff, J. Mauchly, J. P. Eckert, H. Aiken, ...