Injury to peripheral nerves often results in a persistent neuropathic pain condition that is characterized by spontaneous pain, allodynia, and hyperalgesia. Nerve injury is accompanied by a local inflammatory reaction in which nerve-associated and immune cells release several pronociceptive mediators. Kinin B1 receptors are rarely expressed in nontraumatized tissues, but they can be expressed a...

objective(s): we investigated the histopathological effects of metamizole sodium (ms) on the sciatic nerve.  materials and methods: this study was performed using 48 adult male wistar albino rats. ten groups were constituted with 6 rats in each group. ms injection into the sciatic nerve (group 1), ms injection into the muscle [group 3 (50 mg/kg, 0.4 ml) and group 5 (50 mg/kg, 0.8 ml)], ms injec...

Peripheral nerve injury produces a persistent neuropathic pain state characterized by spontaneous pain, allodynia and hyperalgesia. In this study, we evaluated the possible involvement of A 2ARs in the development of neuropathic pain and the expression of microglia and astrocytes in the spinal cord after sciatic nerve injury. For this purpose, partial ligation of the sciatic nerve was performed...

Apple Cider Vinegar (ACV) is a natural compound that is used mainly in numerous food preparations. During the last few decades, ACV has been used for various therapeutic purposes in different countries. One of its main applications by people in Iran and other countries has been as an oral traditional remedy to control chronic pain in arthritis. In this study, ACV’s effects on acute and chronic ...

a 28-year-old man with neurofibromatosis type 1(nf1) presented with a tumor in the sciatic nerve and femoral nerve. the differential diagnosis of malignant peripheral nerve sheath tumor was based on clinical, radiological, and histological evidence. the tumor apparently originated in sciatic nerve at the posterior aspect of the left thigh. the lesion was resected totally without neural damage t...

In a recent study, Wattanathorn et al. identified that the combined extract of purple waxy corn and ginger was effective in improving functional and structural changes in STZ-diabetic rats submitted to chronic constriction of the sciatic nerve, an effect that is potentially mediated by the antiox-idant properties of these combined extracts. Although the results have been quite interesting, we w...

In addition to the known retrograde transport of neurotrophins, it is now evident that endogenous brain-derived neurotrophic factor (BDNF) is transported in the anterograde direction in peripheral and central neurons. We used a double-ligation procedure that distinguishes between anterograde and retrograde flow to quantify the anterograde transport of endogenous neurotrophins and neuropeptides ...

BACKGROUND AND OBJECTIVE Optical coherence tomography (OCT) has been used in limited settings to study peripheral nerve injury. The purpose of the study is to determine whether high-resolution OCT can be used to monitor nerve injury and regeneration in the rat sciatic nerve following crush injury, ligation, and transection with microsurgical repair. STUDY DESIGN/MATERIALS AND METHODS Forty-fi...

Introduction It is now very well known that events like nerve ligation directly causes mechanical injury to the nerve and symptoms produced in such animals resemble the symptoms produced in causalgia in humans. The animal model mimics both hyperalgesia (increased response to noxious stimuli) and allodynia (pain response to low threshold stimulus) [1–4]. Furthermore, it is also reported that ext...