primary cutaneous anaplastic large cell lymphoma is a t-cell malignancy with atypical cd30 positive lymphocytes. pseudoepitheliomatous hyperplasia is an uncommon finding in primary cutaneous anaplastic large cell lymphoma, and may mimic squamous cell carcinoma as pseudomalignancy. careful attention of a pathologist to correct diagnosis of pseudoepitheliomatous hyperplasia and its underlying cau...

Background: The most frequently mutated tumor suppressor gene found in human cancer is p53. In a normal situation, p53 is activated upon the induction of DNA damage to either arrest the cell cycle or to induce apoptosis. However, when mutated, p53 is no longer able to properly accomplish these functions. The aim of this study was to investigate the expression of p53 gene in cases of skin cancer...

BACKGROUND C-reactive protein (CRP) is inversely related to prognosis in many cancers, however, no studies regarding the predictive value of CRP in small cell carcinoma of the esophagus (SCCE) are available. The aim of this study was to determine the prognostic value of preoperative CRP in patients with SCCE. METHODS From January 2001 to December 2010, a retrospective analysis of 43 consecuti...

skin cancer is one of the most important type of cancers in the world. in this way, molecular investigation in order to detect some novel mechanisms and polymorphisms involved in cancer development can be impressive and vital. in this way, the aim of this study was the histopathological investigation of skin cancer and its relationship with polymorphism of cdkn2a gene. this case-control study w...

a primary intraosseous carcinoma (pioc) is a squamous cell carcinoma arising within the  jawbone andshould be differentiated from a malignant ameloblastoma.  it  is not due to arising from an odontogenic cyst or tumor. the possibility of the lesion being  a metastasis fromanotherprimary site should be considered, and excluded by a careful history and examination. the diagnosis of a pioc is rare...

Eosinophilic esophagitis (EE) is an increasingly recognized primary clinicopathologic disorder of the esophagus which lacks a specific etiology. Most reports on EE have been limited to the esophagus mucosa. We present a 56-year-old man with the mural form of EE and superficial squamous cell carcinoma in the esophagus. The eosinophils diffusely invaded the full-thickness of the esophagus, mainly...

Histologic changes suggesting HPV infection are occasionally found adjacent to squamous cell carcinoma or in squamous papilloma of the esophagus, but the relationship between HPV infection and benign and malignant squamous lesions of the esophagus is not yet dear. The aim of this study was to examine the role of HPV in squamous lesions of the esophagus. Microscopic examination with emphasis on ...

primary de novo intraosseous carcinoma is a rare neoplastic lesion which commonly occurs in the jaws. it is an epithelial odontogenic malignancy arising from odontogenic epithelial residues in the bone rather than from a preexisting epithelial lesion. in the present case report, the clinical, radiological and histological features of primary de novo intraosseous carcinoma are discussed and its ...

ocular surface may be involved by different neoplastic lesions ranging from benign to highly malignant. recognition of risk factors, clinical presentations, pathology, and different therapeutic modalities is essential for selecting an appropriate approach. this article deals with the proper approach to ocular surface squamous neoplasia (ossn) including conjunctival/corneal intraepithelial neopl...

background & objectives:  cd10 is a cell surface enzyme with metalloendopeptidase activity, also known as common acute lymphoblastic leukaemia antigen, which mainly serves as a marker for acute lymphoblastic leukemia (all). to date and to the best of our knowledge, only few comparative immunohistochemical studies have assessed cd10 expression in cutaneous epithelial neoplasms. our goal was ...