BACKGROUND Patients with irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD) commonly experience diarrhea, abdominal pain, bloating, and urgency. These symptoms significantly compromise the patient's quality of life (QoL) by limiting participation in normal daily activities and adversely affect work productivity and performance. PURPOSE The aim of this study was to understand f...

Background and Purpose—Silent brain infarcts (SBI) and white matter lesions are relatively common neuroimaging findings, especially in the elderly population. The genetic background for SBI and white matter lesions in a large Japanese general population was investigated. Methods—Subjects were recruited from participants in the National Institute for Longevity Sciences, Longitudinal Study of Agi...

A distinction is made between the clinical and public health justifications for screening and brief intervention (SBI) against hazardous and harmful alcohol consumption. Early claims for a public health benefit of SBI derived from research on general medical practitioners' (GPs') advice on smoking cessation, but these claims have not been realized, mainly because GPs have not incorporated SBI i...

BACKGROUND AND PURPOSE Silent brain infarction (SBI) is often found with white matter hyperintensity. A recent genetic study on elderly twins indicated that the susceptibility to white matter hyperintensity was largely determined by genetic factors, implying the existence of genetic susceptibility for SBI as well. We therefore studied 3 genetic polymorphisms in SBI, the deletion/insertion polym...

BACKGROUND AND PURPOSE Silent brain infarcts (SBIs) have been recognized as common lesions in elderly subjects and their diagnosis relies on brain imaging. In this study, we aimed to evaluate the different MRI parameters and criteria used for their evaluation in the literature to better understand the variation across studies and related limitations. METHOD Original MRI studies of SBI perform...

The ansa-zirconocene complex rac-Me(2)Si(1-indenyl)(2)ZrCl(2) ((SBI)ZrCl(2)) reacts with diisobutylaluminum hydride and trityl tetrakis(perfluorophenyl)borate in hydrocarbon solutions to give the cation [(SBI)Zr(μ-H)(3)(Al(i)Bu(2))(2)](+), the identity of which is derived from NMR data and supported by a crystallographic structure determination. Analogous reactions proceed with many other zirco...

Early diagnosis of serious bacterial infections (SBI) in febrile young infants based on clinical symptoms and signs is difficult. This study aimed to evaluate the diagnostic values of circulating chemokines and C-reactive protein (CRP) levels in febrile young infants < 3 months of age with suspected SBI. We enrolled 43 febrile young infants < 3 months of age with clinically suspected SBI who we...

Substantial empirical support exists for alcohol screening and brief intervention (SBI) in medical settings but not in nonmedical settings such as the workplace—a potential but underutilized venue for alcohol SBI. This research aims to translate medical SBI into behavioral health-care practice in US work settings, where millions of workers might be reached annually. The primary objectives of th...

Intestinal barrier dysfunction is associated with chronic gastrointestinal tract inflammation and diseases such as IBD and IBS. Serum-derived bovine immunoglobulin/protein isolate (SBI) is a specially formulated protein preparation (>90%) for oral administration. The composition of SBI is greater than 60% immunoglobulin including contributions from IgG, IgA, and IgM. Immunoglobulin within the l...

ISSUES Many policy review articles have concluded that alcohol screening and brief intervention (SBI) is both cost-effective and cost-beneficial. Yet a recent cost-effectiveness review for the United Kingdom's National Institute for Health and Clinical Excellence suggests that these conclusions may be premature. APPROACH This article offers a brief synopsis of the various types of economic an...