Soft tissue sarcomas are a heterogeneous group of tumors with many different subtypes. In 2014 an estimated 12,020 newly diagnosed cases and 4,740 soft tissue sarcoma related deaths can be expected in the United States. Many soft tissue sarcomas are associated with poor prognosis and therapeutic options are often limited. The evolution of precision medicine has not yet fully reached the clinica...

Head and neck (HN) sarcomas constitute about 5-10% of all sarcomas and only 1% of all HN tumor types. According to the limited work published to date about HN sarcomas, histological subtype is a significant prognostic factor in addition to tumor size, Histological Grade (HG), depth of invasion, HN location and surgical resection margin status [1]. Fibrosarcoma, undifferentiated pleomorphic sarc...

The purpose of this communication is to bring up to date an experimental study of 55 chemically induced fowl sarcomas, first described some 12 years ago (16-18), and to compare these results with others obtained in parallel experiments with 3 infective fowl sarcomas transmissible by cell-free material. The bearand from further discussion, because they retrogressed during the first serial passag...

OBJECTIVE To quantify incidence of vaccination practices, postvaccinal reactions, and vaccine site-associated sarcomas in cats. DESIGN Epidemiologic survey. Animals-31,671 cats vaccinated in the United States and Canada by veterinarians with World Wide Web access. PROCEDURE Veterinarians used secure Web-based survey forms to report data regarding administered vaccines, postvaccinal inflamma...

Positron emission tomography (PET) using 2-deoxy-2-[(18)F] fluoro-D-glucose ((18)F-FDG) has been used with increased frequency in the care of patients with soft tissue sarcomas to predict malignant potential of tumours, prognosis of survival and response to chemotherapy. Although there are several other PET tracers, which have found limited use in sarcomas, this review focuses on the use of (18...

The etiology of feline injection-site sarcomas remains obscure. Sarcomas and other tumors are known to be associated with viral infections in humans and other animals, including cats. However, the available evidence suggests that this is not the case with feline injection-site sarcomas. These tumors have more in common with sarcomas noted in experimental studies with laboratory animals where fo...

OBJECTIVE To determine the pattern of occurrence of sarcomas afflicting the neck and craniofacial region. DESIGN A retrospective study (1982-1991). SETTING Cancer Registry, Kenyatta National Hospital, Nairobi, Kenya. METHOD Examination was performed of the cancer records in the registry over the period 1982 to 1991 inclusive. Histopathological types of the sarcomas were then analysed to i...

Primary sarcomas of the great vessels (aorta, pulmonary artery, and inferior vena cava (IVC)) are exceedingly rare. We report a rare case of an undifferentiated intimal sarcoma of the IVC with extension to the right atrium, adrenal, and renal veins. The patient underwent extensive resection, reconstruction of the IVC, and subsequent adjuvant chemotherapy. Patient has tolerated chemotherapy and,...

Sarcomas are highly aggressive heterogeneous tumors that are mesenchymal in origin. There have been vast advancements on identifying diagnostic markers for sarcomas including chromosomal translocations, but very little progress has been made to identify targeted therapies against them. The tumor heterogeneity, genetic complexity and the lack of drug studies make it challenging to recognize the ...

BACKGROUND Cyclooxygenase-2 (Cox-2) is expressed by several types of epithelial malignancies, i.e., carcinomas, and inhibition of Cox-2 may have a therapeutic role in chemoprevention and treatment of cancer. The role of Cox-2 in non-epithelial malignancies, however, is unclear. MATERIALS AND METHODS We investigated, by immuno- histochemistry, the expression of Cox-2 in 103 human soft-tissue s...