The human adult parotid duct is the longest of all major salivary gland ducts, approximately 6-8 cm in length. Its unique structure extends over the masseter muscle, penetrates through the buccinator muscle and opens into the oral cavity. Salivary secretion is under basic control of the sympathetic and parasympathetic divisions of the autonomic nervous system. Scarce reporting on the parotid du...

During both acute and chronic mineralocorticoid administration, parotid saliva was obtained by acetylcholine stimulation at rates of 1-0—1 -5 mlmin" from anaesthetized red kangaroos. The Na/K ratio of saliva from chronically Na-replete kangaroos was virtually unaltered by ipsilateral intracarotid infusion of aldosterone at rates of 8, 40 or 80/igh" for 4h, the ratio falling from 20-1 ± 1-09 to ...

Sialoliths are the most common diseases of the salivary glands. They may occur in any of the salivary gland ducts but are most common in Wharton's duct and the submandibular gland. This report presents clinical and radiographical signs of two unusually large sialoliths. There were painless swellings on the floor of the mouth in both cases. Radiographical examination revealed large irregular rad...

Sialolithiasis stands for the most etiology of salivary gland obstruction which leads to recurrent painful swelling of the involved gland which often increases while eating. Stones may be seen in any of the salivary glands but mostly seen in submandibular gland and its ducts. Here is a case of 47 years old male patient who had a giant submandibular sialolith. Orthopantomograph was used to confi...

A healthy salivary gland secretes saliva in two stages. First, acinar cells generate primary saliva, a plasma-like, isotonic fluid high in Na(+) and Cl(-). In the second stage, the ducts exchange Na(+) and Cl(-) for K(+) and HCO(3)(-), producing a hypotonic final saliva with no apparent loss in volume. We have developed a tool that aims to understand how the ducts achieve this electrolyte excha...

We have recently shown that salivary gland myoepithelial cells express podoplanin. Podoplanin indirectly binds the actin filament network which links classical cadherins. The study here is aimed to investigate the expression of podoplanin and cadherins on salivary gland myoepithelial cells and the changes in the aging cells using klotho-deficient (kl/kl) mice. The submandibular glands of kl/kl ...

The Mucocele or Mucus Extravasation phenomenon or mucus escape reaction is a common benign lesion of the oral cavity which most commonly results from the rupture of a salivary gland ducts or an alternation of minor salivary glands due to accumulation of mucus into the surrounding soft tissues. This may results from the local trauma to the salivary ducts that can be produced by lip or cheek bitt...

The localization of dopamine stores and the expression and localization of dopamine (DAT) and vesicular monoamine transporters (VMAT) type-1 and -2 and of dopamine D1-like and D2-like receptor subtypes were investigated in rat submandibular, sublingual, and parotid salivary glands by HPLC with electrochemical detection, as well as immunochemical and immunohistochemical techniques. Male Wistar r...

OBJECTIVES To introduce a technical modification for interruption of the parotid and submandibular salivary ducts and to demonstrate the technique's effectiveness and effect on quality of life. DESIGN Retrospective, uncontrolled, consecutive case series. SETTING A tertiary care pediatric otolaryngology practice. PATIENTS Eighteen drooling and aspirating children. INTERVENTION Transoral ...

The development of the submandibular gland is mediated by epithelial-mesenchymal interactions; acini and ducts are immature at birth proliferate differentiate after birth. Limited information available on epigenetic modifications via histone during early phase salivary development. Therefore, present study examined changes in expression localization Jmjd3 to clarify role H3K27me3 modification p...