Manganese-salen complexes (Mn-Salen), including EUK-8 [manganese N,N'-bis(salicylidene)ethylenediamine chloride] and EUK-134 [manganese 3-methoxy N,N'-bis(salicylidene)ethylenediamine chloride], have been reported to possess combined superoxide dismutase (SOD) and catalase mimetic functions. Because of this SOD/catalase mimicry, EUK-8 and EUK-134 have been investigated as possible therapeutic a...

Dimethyl-, diethyl-, and diphenyl-substituted analogues of nickel(II) salen have been synthesized, and the cyclic voltammetric behavior of each compound at a glassy carbon electrode in dimethylformamide (DMF) containing tetra-n-butylammonium tetrafluoroborate (TBABF4) has been compared with that of nickel(II) salen itself. Differences in the cathodic peak potentials for these species have been ...

The fluorescence spectral characteristics and interaction of bis(ethylene)tin(bis(salicylidene)ethylenediamine) [Et2Sn(salen)] with DNA are described. The polarity of the solvent has a strong effect on the fluorescence characteristics of Et2Sn(salen). Et2Sn(salen) bound to DNA showed a marked decrease in the fluorescence intensity with a bathochromic shift of the excitation and emission peaks. ...

The alkane elimination reaction between Salen((t)Bu)H(2) ligands and diethylaluminum bromide was used to prepare three Salen aluminum bromide compounds salen((t)Bu)AlBr (1) (salen = N,N'-ethylenebis(3,5-di-tert-butylsalicylideneimine)), salpen((t)Bu)AlBr (2) (salpen = N,N'-propylenebis(3,5-di-tert-butylsalicylideneimine)), and salophen((t)Bu)AlBr (3) (salophen = N,N'-o-phenylenenebis(3,5-di-ter...

Reaction of benzaldehyde with ethyl cyanoformate in the presence of Lewis acidic Ti(IV) complexes of bispyridylamide or salen ligands and Lewis basic amines affords the O-alkoxycarbonylated cyanohydrin. In the presence of the salen-based catalytic system, acetyl cyanide can also be added to benzaldehyde, providing a highly enantioselective direct route to the O-acetylated cyanohydrin.

Research interests: Asymmetric catalysis for organic synthesis, including chiral diaminocarbene ligands and VHOIɅDVVHPEOHGGLQXFOHDU catalysts; development of VPDOOPROHFXOHDQWLɅFDQFHU agents; and total synthesis of complex molecules with interesting biological activities. Abstract Novel chiral Co-salen catalysts capable of self-assembly through hydrogen bonding have been developed. First, a self...

A new chiral salen ligand based on two ferrocenyl groups is designed. Unlike known salen ligands, of which chirality originates from central and axial chiral centers, the chirality of this ligand comes from the planar chiral ferrocenyl groups. The ligand is synthesized stereoselectively using a novel aromatization strategy starting from a ferrocene derivative, which was readily prepared using a...

Two unprecedented 2D entangled layers of warp-and-woof threads interwoven by left- and right-handed helical chains, {[Mn(salen)Au(CN)2]4(H2O)}n (salen = N,N'-ethylenebis(salicylideneaminato)) and {Mn(acacen)Ag(CN)2}n (acacen = N,N'-ethylenebis(acetylacetonylideneiminate)) 2, have been synthesized and characterized.

The theoretical study of Mn(salen) catalysts has been traditionally performed under the assumption that Mn(acacen') (acacen' = 3,3'-(ethane-1,2-diylbis(azanylylidene))bis(prop-1-en-olate)) is an appropriate surrogate for the larger Mn(salen) complexes. In this work, the geometry and the electronic structure of several Mn(salen) and Mn(acacen') model complexes were studied using Density Function...