Abstract Funding Acknowledgements Type of funding sources: None. Background Automatic capture algorithms periodically measure the minimal quantity current needed for pacing, self-adjusting output to guarantee consistent myocardial capture, enhancing patient safety in case an unexpected rise threshold and reducing drain. Left bundle branch area pacing (LBBAP) is emerging conduction system (CSP) ...

This paper uses a threshold based mathematical definition to estimate capacity for future sUAS traffic in low altitude uncontrolled airspace based on safety and performance considerations. It is motivated by the need to assess the impact of large-scale close proximity unmanned aircraft operations on communities and existing manned airspace. We simulate unmanned traffic over urban areas and esti...

This white paper lays out some foundational information about different approaches to safety: how various industries differ in their approaches to safety engineering, and a comparison of three general approaches to safety (system safety, industrial safety engineering, and reliability engineering). An attempt is made to lay out the properties of industries and systems that make one approach more...

Growing evidence supports a 1972 proposal that dynamic tension strains of a ligament above a threshold range, but below its ultimate strength, would make its cells synthesize more collagen to thicken and strengthen it. If so, when that strengthening reduced later strains to the bottom of that threshold range this "diametric modeling" would stop. A) Such a mechanism must create a "strength-safet...

Nocturnal hypoglycemia is a barrier to therapy intensification efforts in diabetes. The Paradigm® Veo™ system may mitigate nocturnal hypoglycemia by automatically suspending insulin when a prespecified sensor glucose threshold is reached. ASPIRE (Automation to Simulate Pancreatic Insulin REsponse) In-Home (NCT01497938) was a multicenter, randomized, parallel, adaptive study of subjects with typ...

in this research, air sampling of workplaces was carried out by two methods (long - time and short - time). the mean formaldehyde concentration with long - time method in pathology labs, surgery and endoscopy sections were 0.96 0.25 and 0.13 ppm and with short - time method, 8 hours, was 3, 0.3 and 0.2 ppm. the mean formaldehyde concentration in pathology labs was above the standard values (tlv...

A commonly referenced transcranial Direct Current Stimulation (tDCS) safety threshold derives from tDCS lesion studies in the rat and relies on electrode current density (and related electrode charge density) to support clinical guidelines. Concerns about the role of polarity (e.g. anodal tDCS), sub-lesion threshold injury (e.g. neuroinflammatory processes), and role of electrode montage across...

Safety case development is not a post-development activity, rather it should occur throughout the system development lifecycle. The key components in a safety case are safety arguments. Too often, safety arguments are constructed without proper reasoning. Inappropriate reasoning in safety arguments could undermine a system’s safety claims, which in turn contributes to safety-related failures of...

a b s t r a c t there are three types of nerve fibers that are involved in the transmission of pain stimuli: c fibers (slower fibers) for thermal, mechanical and chemical stimuli, a-delta fibers for thermal or mechanical stimuli and a-beta fibers for touch stimuli. clinically, this is crucial in making an accurate assessment of the pain level experienced by a suffering patient, in indicating th...