insanity as a bodily disease,?for Hippocrates taught that mental diseases were due to the circulation of black bile in the blood,?our present knowledge of the physical causation of mental disease is sadly deficient and most imperfect. Within a comparatively short lapse of time, I have been fortunate enough to meet with a series of cases, in many of which the close sympathetic connection between...

An extensive range of molecular defects have been identified in the human mitochondrial genome (mtDNA), causing a range of clinical phenotypes characterized by mitochondrial respiratory chain dysfunction. Sadly, given the complexities of mitochondrial genetics, there are no available cures for mtDNA disorders. In this review, we consider experimental, genetic-based strategies that have been or ...

It has been generally known that the agent research community provides powerful theories, algorithms and techniques that have got an immense potential for the deployment in various industrial applications. Sadly noted, the number of agent research centers and groups as much as the number of agent researchers by far outnumbers the commercial companies, CTO, and entrepreneurs that have the courag...

The current-feedback (CMF) amplifier is a fundamentally different approach to high-frequency gain blocks. Not just an input stage, it is a full amplifier topology. It has outstanding characteristics in several areas: very high slewrates, -3dB bandwidth which is almost constant with increasing circuit gain, and low high-frequency distortion. Almost all commercial CMF products offer these benefit...

Every year more than half a million people die in the United Kingdom, and most of these deaths occur in hospitals. While some deaths occur suddenly, the majority of deaths are predictable, occurring after a period of chronic illness. All doctors will at some stage be required to care for patients who are dying and communication is the key to doing this well. Sadly, all too often this is not ach...

Sadly, there are commonly divides between the worlds of theory, practice and policy; in this paper I draw on 20 years experience in the Project for Enhancing Effective Learning (PEEL) and a range of other projects that have involved forms of teacher research to discuss how both the process and the products of teacher research can help bridge these divides. The paper looks at three areas where P...

1 Activities This three-year project was put on hold and restarted midway through the second year after one of its original Co-PIs, Megumi Kameyama, sadly passed away. The project focuses on solutions to the problem of mismatch resolution in machine translation(MT). It proposes to build a prototype MT system called MRT (for Mismatch Resolution Translation) that includes a separate box called a ...

Pedophilia is bad. But how bad is it? And in what ways, and for what reasons, is it bad? This is a thorny issue, and sadly, one seldom discussed by ethicists. I argue in this article that pedophilia is bad only because, and only to the extent that, it causes harm to children, and that pedophilia itself, as well as pedophilic expressions and practices that do not cause harm to children, are mora...

Abstract With the finest biochemical and molecular approaches, convincing explorative strategies, long-term vision, Stefan Hörtensteiner succeeded in elucidating pathway responsible for chlorophyll degradation. After having contributed to identification of key degradation products course past 25 years, he gradually identified characterized most crucial players PAO/phyllobilin chlorophyll. He wa...

Unfortunately, the amount and timeliness of this literature suggests a sad fact. The problem of incivility and lack of respect in the workplace is getting worse, not better. Nurses are notorious for not respecting each other. The worn out cliché’ of “nurses eat their young” is, sadly, still relevant. Regrettably, it is not just new nurses who are treated poorly. More aggressive, more powerful n...