Short-acting 2-agonists (SABA) are used in asthma and chronic obstructive pulmonary disease (COPD) treatment because of their capacity to relax smooth muscle, their rapid symptoms relief and their acceptable safety profile. Salbutamol and terbutaline are the most frequently used SABA. Although SABA present an acceptable safety profile as above-mentioned, several adverse effects have been descri...

Heart failure (HF) is often associated with pulmonary congestion, reduced lung function, abnormal gas exchange, and dyspnea. We tested whether pulmonary congestion is associated with expanded vascular beds or an actual increase in extravascular lung water (EVLW) and how airway caliber is affected in stable HF Subsequently we assessed the influence of an inhaled short acting beta agonist (SABA)....

CRTH2: Chemoattractant Receptor-Homologous Molecule Expressed On Th2 Cells; COPD: Chronic Obstructive Pulmonary Disease; WHO: World Health Organization; SIT: Allergen-Specific Immunotherapy; ICS: Inhaled Corticosteroids; LABA: LongActing-Β-Agonist; SABA: Short-Acting-Β-Agonist; MDI: Metered Dose Inhaler; 5-LO: 5-Lipoxygenase; FLAP: 5-LipoxygenaseActivating Protein; 5-Oxo-ETE: 5-Oxo-6,8,11,14-Ei...

BACKGROUND Omalizumab is a monoclonal antibody, indicated for the treatment of severe allergic asthma. In Europe, there have been concerns about the cardiovascular safety of omalizumab. The objective of this study was to analyze the association between omalizumab and arterial thrombotic events in a spontaneous adverse drug reaction reporting database in the US. METHODS AND MATERIALS Reports o...

Short-acting 2-agonists (SABA) are used in asthma and chronic obstructive pulmonary disease (COPD) treatment because of their capacity to relax smooth muscle, their rapid symptoms relief and their acceptable safety profile. Salbutamol and terbutaline are the most frequently used SABA. Although SABA present an acceptable safety profile as above-mentioned, several adverse effects have been descri...

The Ulster Medical Society grants to all users on the basis of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Licence the right to alter or build upon the work non-commercially, as long as the author is credited and the new creation is licensed under identical terms. 4. Derouin F, Bultel C, Roze S. AFSSA (Agence Française de Sécurité Sanitaire des Aliments). Toxoplasm...

BACKGROUND Inhaled short acting β2-agonists (SABA), e.g. albuterol, are used for quick reversal of bronchoconstriction in asthmatics. While SABA are not recommended for maintenance therapy, it is not uncommon to find patients who frequently use SABA over a long period of time and there is a suspicion that long term exposure to SABA could be detrimental to lung function. To test this hypothesis ...

In this exclusive interview between Pakistani authors Saba Karim Khan and Mohsin Hamid, Hamid discusses his complex relationship with the concept of home.