The functional interactions between neurons and glial cells that are important for nervous system function are presumably established during development from the activity of progenitor cells. In this study we examined proliferation of progenitor cells in the medial nucleus of the trapezoid body (MNTB) located in the rat auditory brainstem. We performed DNA synthesis labeling experiments to demo...

BACKGROUND This study aimed to evaluate the effects of lidocaine treatment on cognitive impairment in aged patients undergoing spine surgery and to explore the underlying mechanism. MATERIAL/METHODS Patients were randomly divided into 2 treatment groups: (1) saline (control) and (2) lidocaine. After induction of anesthesia, the lidocaine group received lidocaine as a bolus of 1 mg/kg over 5 m...

Obesity has been reported to be one of the significant contributors to various chronic disease conditions. Childhood obesity has been on an alarming increase over recent years leading to various health complications. Millions of children undergo surgery each year as a part of medical care on various health grounds. In the present study, influence of vitamin C on the effect of obesity and over-w...

for making both diagnoses and prognoses of neurological injury. Of the more than 20 isoforms in the S100 protein family, S100ß displays unique biomarker and diagnostic properties in ectodermic derived normal neurons and certain malignancies. The purpose of this focused review is to highlight and discuss findings that support the notion that S100ß can be used as a biomarker to indicate the prese...

The aim of the present study was to analyze the protective and hemodynamic effects of dexmedetomidine in hypertensive cerebral hemorrhage (HCH) patients during perioperative period. In total, 50 HCH patients were selected and randomly divided into two groups, one group was administered with dexmedetomidine and the other groups with midazolam. The mean arterial pressure (MAP), heart rate (HR) an...

Background. The purpose of the work was to determine level S100β protein in children with COVID-19 and investigate correlation this neurobiomarker severity age patients. Materials methods. We conducted a retrospective, cohort, observational, post-registration study. examined 88 aged 1 month 17 years laboratory-confirmed who underwent inpatient treatment at Kyiv City Children’s Clinical Infectio...

Mutations in WD40-repeat protein 62 (WDR62) are commonly associated with primary microcephaly and other developmental cortical malformations. We used human pluripotent stem cells (hPSC) to examine WDR62 function during human neural differentiation and model early stages of human corticogenesis. Neurospheres lacking WDR62 expression showed decreased expression of intermediate progenitor marker, ...