The sequences complementary to the nascent RNA molecules isolated from transcription complexes of HeLa cell mtDNA have been mapped on the H and L strands of mtDNA by the S1 protection technique. The distribution of these sequences among different Hpa II restriction fragments was found to reflect the position of these fragments in the Hpa II map of mtDNA. Thus, the S1-resistant hybrids formed wi...

We have examined the S1 nuclease sensitivity in the promoter of both the chicken and mouse alpha 2(I) collagen genes. When these DNAs are introduced into supercoiled plasmids and digested with S1 nuclease, a discrete region containing one or more cleavages is found in each promoter. These S1 cleavage sites were mapped by the distance of the S1 site from known restriction enzyme cleavage sites. ...

The S1 element is a plant short interspersed element (SINE) that was first described and studied in Brassica napus. In this work, we investigated the distribution and the molecular phylogeny of the S1 element within the Cruciferae (= Brassicaceae). S1 elements were found to be widely distributed within the Cruciferae, especially in species of the tribe Brassiceae. The molecular phylogeny of S1 ...

We analyze the approximation order associated with a directed set of spaces, {Sh}h>0, each of which spanned by the hZZ-translates of one compactly supported function φh : IR s → C. Under a regularity condition on the sequence {φh}h, we show that the optimal approximation order (in the ∞-norm) is always realized by quasi-interpolants, hence in a linear way. These quasi-interpolants provide the b...

  Bluetongue is an infectious disease that primarily affects sheep. But due to serious socioeconomic consequence of it outbreaks on the international trade it has been included in the OIE notifiable diseases (list A). During 2007-8, total number of 130 blood samples gathered from suspected sheep to bluetongue disease in seropositive region including Khuzestan, Kurdistan, Fars, Ilam and Qum prov...

Bioinformatics can play a special role in studying emerging infectious diseases, where a fast characterization of the diseases is often urgently needed before they are widespread. In this chapter, we described a computational framework for fast modeling of emerging infectious diseases, including five components: (1) gene survey of the biological sequences rela ted to the emerging diseases; (2) ...

We have identified a novel exon 11 of the human prolactin receptor (hPRLR) gene that is distinct from its rodent counterparts and have demonstrated the presence of two novel short forms of the hPRLR (S1(a) and S1(b)), which are derived from alternative splicing of exons 10 and 11. S1(a) encodes 376 amino acids (aa) that contain partial exon 10 and a unique 39-aa C-terminal region encoded by exo...

Abdominal visceral adipose tissue (AT) accumulation is associated with an atherogenic metabolic profile that includes increased plasma triglyceride (TG), low HDL cholesterol levels, and an insulin-resistant hyperinsulinemic state. Whereas the apolipoprotein (apo) C-III C3238G gene variant, often referred to as the SstI polymorphism, has been related to variations in plasma TG concentrations, an...

Limbic encephalitis is an adaptive autoimmune disease, induced by different autoantibodies, which target extracellular neuronal epitopes, such as NMDA or GABAB receptors1,2. Recently our group found another human antibody, which binds to the α1 subunit of the GABAA receptor. Since the GABAA receptor is responsible for the majority of fast inhibitory neurotransmission, we investigated chan...