Airway epithelial cells play a major role in initiating inflammation in response to bacterial pathogens. S. aureus is an important pathogen associated with activation of diverse types of infection characterized by inflammation dominated by polymorphonuclear leukocytes. This bacterium frequently causes lung infection, which is attributed to virulence factors. Many of virulence determinants assoc...

Objective(s): Obstructive sleep apnea (OSA) is confirmed to cause lesions in multiple organs, especially in the lung tissue. Tempol is an antioxidant that has been reported to restrain inflammation and oxidative stress, with its role in OSA-induced lung injury being unclear. This study aimed to investigate the beneficial effect of tempol on chronic intermittent hypoxia (IH)-induced lung injury....

SCY1-like 1-binding protein 1 (SCYL1BP1) is a newly identified transcriptional activator domain containing protein with many unknown biological functions. Recently emerging evidence has revealed that it is a novel regulator of the p53 pathway, which is very important for the development of human cancer. However, the effects of SCYL1BP1 on human lung squamous carcinoma cell biological behavior r...

We proposed a novel measure of mutual information known as Integration to Segregation (I2S) explaining the relationship between two features. We investigated its nontrivial characteristics while comparing its performance in terms of class imbalance measures. We have shown that I2S possesses characteristics useful in identifying sink and source (parent) in a conventional directed acyclic graph i...

This document specifies conventions for X.509 certificate usage by Secure/Multipurpose Internet Mail Extensions (S/MIME) v3.2 agents. S/MIME provides a method to send and receive secure MIME messages, and certificates are an integral part of S/MIME agent processing. S/MIME agents validate certificates as described in RFC 5280, the Internet X.509 Public Key Infrastructure Certificate and CRL Pro...

Release notes for dense-core vesicles V an de Bospoort et al. describe how Munc13 proteins control when and where dense-core vesicles (DCVs) are released from neurons. Neuronal DCVs contain neuropeptides and other factors that promote brain development and modulate synaptic transmission. Like neurotransmitter-containing synaptic vesicles (SVs), DCVs are released in response to action potentials...

considering the importance of the factors affecting customer satisfaction and loyalty, this study aimed to investigate the relationship between performance and characteristic of a online stores – digi-kala in this particular case, as a perfect example of an electronic customer relationship system, and customer's electronic loyalty and satisfaction. as a practical-descriptive, research, ele...