OBJECTIVE To test the hypothesis that pain patients differ from well children in their appraisal and coping with daily stressors and to test a model of the relation of stress appraisal and coping to symptoms and disability. METHODS Pediatric patients with chronic abdominal pain (n = 143) and well children (n = 104) completed a 5-day diary study regarding their appraisal and coping with daily ...

The PepQ prolidase from Escherichia coli catalyzes the hydrolysis of dipeptide substrates with a proline residue at the C-terminus. The pepQ gene has been cloned, overexpressed, and the enzyme purified to homogeneity. The k(cat) and k(cat)/K(m) values for the hydrolysis of Met-Pro are 109 s(-1) and 8.4 x 10(5)M(-1)s(-1), respectively. The enzyme also catalyzes the stereoselective hydrolysis of ...

Epithelial cells at environmental interfaces provide protection from potentially harmful agents, including pathogens. In addition to serving as a physical barrier and producing soluble mediators of immunity, such as cytokines or antimicrobial peptides, these cells are thought to function as nonprofessional APCs. In this regard, intestinal epithelial cells are particularly prominent because they...

Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S in peripheral APCs have both been implicated in the last step of Ii degradation that gives rise to the class II-associated invariant chain peptides (CLIP). Cat V has been recently described as highly homologous to Cat L an...

Chemical oxidation of a Mo(3)S(7) cluster featuring catecholate ligands, namely [Mo(3)S(7)(Cl(4)cat)(3)](2-) (Cl(4)cat = tetrachlorocatecholate), allows the isolation of a unique nanoscopic molecular cage made of four iodide-bridged Mo(3)S(7) clusters as the kinetically favoured product.

Cathepsins regulate premature trypsinogen activation within acinar cells, a key initial step in pancreatitis. The identity, origin, and causative roles of activated cathepsins in pancreatic inflammation and pain are not defined. By using a near infrared-labeled activity-based probe (GB123) that covalently modifies active cathepsins, we localized and identified activated cathepsins in mice with ...

objectives:  stroke is a major event in one's life, and patients will inevitably require the use of coping strategies in order to try to reestablish acceptable life equilibrium. due to the extensive role that nurses can be active members in the patient's rehabilitation plan, the mauk model is a model that focuses on stroke patients. for each stage of this model,  mauk has developed ap...

introduction:One of the most important chalenges in studing the anxiety disorders like PTSD is ethical limits in order to make the animal anxious. Sometimes  this anxiety should last for a long time such as rodent models of PTSD, and this needs aggressive proceses on rats.We found a new approach for a rodent model of PTSD, wich seems to be more efficient and ethical. Materials and Methouds...

OBJECTIVES To correlate the presence and levels of total mercury (THg) in cord blood and meconium indicating prenatal exposure with developmental milestones at 2 years and to compare these subjects with controls of comparable age using cognitive adaptive test and clinical linguistic auditory milestone scale (CAT/CLAMS). METHODS In 48 of the original Tagum (T) subjects, cord blood and meconium...