background and aims: epigallocatechin-3-gallate (egcg) is a polyphenolic compound from green tea, which its anticancer effects on many types of cancers have been confirmed, but the molecular mechanism by which egcg induces apoptosis remains unknown. the aim of the present study was to investigate anti-proliferative properties and apoptotic signaling pathway of egcg on pc3 human prostate cancer ...

background: viscerotropic leishmaniasis caused by leishmania tropica poses a significant prob­lem in the diagnosis and treatment management. since differential gene expression is more im­portant in outcome of the infection, we employed proteomic approach to identify potential pro­teins involved in visceralization of l. tropica . methods: the proteomes profiling of l. tropica isolated from cutan...

objective: several studies have implicated the 5-httlpr polymorphism in treatment outcomes of selective serotonin re-uptake inhibitors in patients with major depression. the aim of this study was to examine the association between polymorphism in the serotonin transporter gene and citalopram effectiveness in iranian patients suffering from major depressive disorder (mdd). methods: the sample co...

background: in order to diagnose the site of thrombi, radiolabeled streptokinase can be prepared. the radiolabeled compound can be used in imaging of thrombi in many cardiovascular diseases. materials and methods: streptokinase was successively labeled with [67ga]-gallium chloride using cyclic dtpa-dianhydride. the conjugation with dtpa was optimized for concentration, time and temperature foll...

brassinosteroids are phytohormones possessing a wide spectrum of antistress activity. to seewhether this hormone is able to ameliorate the effects of water stress, the effects of 24-epibrassinolise onplant growth, accumulation of osmolytes (proline, sugars and ions), lipid peroxidation and electrolyte leakagewere investigated in colza (brassica napus l. cv. fusia) plants which were under water ...

background: matrix metalloproteinase-9 (mmp-9) gene -1562c/t polymorphism could regulate its expression level and thus affected people’s predisposition to essential hypertension. however, related studies yielded inconsistent or contradictory results. methods: to evaluate the association of mmp-9 -1562c/t polymorphism with essential hypertension, we performed a meta-analysis by combining all ava...

objective: epilepsy is a chronic neurological disorder requiring long term therapy using antiepileptic medications. reports have incriminated long term antiepileptic drugs use in deficiency of vitamin d and bone diseases in all age groups. to investigate the association between serum 25-hydroxyvitamin d levels and pediatric epilepsy in indian patients.           methods& methods: we prospective...

objective: perovskia abrotanoides karel, belongs to the family lamiaceae and grows wild alongside the mountainous roads inarid and cold climate of northern iran. the anti-tumor activity of p. abrotanoides root extract has been shown previously. this study was designed to examine in vitro anti-proliferative and pro-apoptotic effects of flower extract of p. abrotanoides on mcf-7 and hela cell lin...