Background The binding of two biological targets with a single IgGbased molecule is thought to be beneficial for clinical efficacy. However the technological challenges for the development of a bispecific platform are numerous. While correct pairing of heterologous heavy and light chains (Hc and Lc) can be achieved by engineering native IgG scaffolds, crucial properties such as thermostability,...

It is shown that the Coulomb energy U of fully ionized ionic mixture can be written as a sum over partial contributions of ion species j: U = T ∑ j Nju(Γj , yj) (generalized linear mixing rule). In contrast to the traditional linear mixing rule ULM = T ∑ j NjuOCP(Γj), applicable for strong coupling, the partial contribution function u depends not only on Γj , but on an additional parameter yj =...

Temperature-dependent viscosity, conductivity and density data of ternary mixtures containing 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)azanide (EMIM-TFSA), ethylene carbonate (EC), and lithium bis(trifluoromethanesulfonyl)azanide (Li-TFSA) were determined at atmospheric pressure in the temperature range of 20 to 80 °C. Differential scanning calorimetry (DSC) measurements were pe...

This paper proposes the refined first order shear deformation theory to investigate the free vibration behavior of bidirectional functionally graded porous plates. This theory satisfies the transverse shear stress free conditions at the top and bottom of the plate, thus avoids the need of a shear correction factor. The rule of mixtures is employed to compute the effective material properties an...

A generalized probability mixture density governs an additive fuzzy system. The fuzzy system’s if-then rules correspond to the mixed probability densities. An additive fuzzy system computes an output by adding its fired rules and then averaging the result. The mixture’s convex structure yields Bayes theorems that give the probability of which rules fired or which combined fuzzy systems fired fo...

as a result of rule of law ideal, judges are required to act in accordance with laws. the ideal is justified by some political values: political liberty, legal liberty , personal liberty and equality. citizens are subject only to the law not to the arbitrary will or judgment of another who wields coercive government power. but in some cases law is indeterminate. in these cases there is an impor...

We applied a mechanistically based model to predict the effects of complex mixtures as occurring in the field on the survival of Daphnia magna. We validated the model by comparing predicted survival with observed survival of in situ exposed laboratory cultured daphnids to polluted surface waters, in which over 90 chemical contaminants were measured. Using the chemical composition of the surface...

densely functionalized 3-(4-chlorophenyl)-5-(3-hydroxy-4-etoxyphenyl)-4,5-dihydro-1h-pyrazole-1-carboxamide was  synthesized in an expedient manner through specification and transamidation  respectively, of ester-functionalized pyrazoles. this synthetic protocol allowed for three diversifying steps in which appendages on the pyrazole scaffold were adjusted to optimize inhibition of protein kina...

This study was conducted in order to evaluate the effects of long term ageing on toughness and resilient modulus of asphalt concrete mixtures containing Electric Arc and Basic Oxygen Furnace steel slags. After initial evaluation of the properties of steel slags using X-ray Diffraction and Scanning Electric Microscope, eleven sets of laboratory mixtures were prepared. Each set was treated replac...