this paper focused on a novel method of electroless plating ruthenium (ru) on solid or porous substrates like porous stainless steel (pss) discs or ceramic tubes. a novel complexing plating bath of ru was developed. it is proven that ru can be deposited directly on these substrates by the bath at a temperature of 328 k and strong alkaline environment. tga, sem, edx and xrd confirmed the success...

The prolactin (PRL) release-inhibitory effects of progesterone, dexamethasone, megestrol acetate, and mifepristone (RU 38486) were studied in cultured pituitary tumor cells prepared from the 7315a and 7315b tumor. Both tumors contain similar numbers of estrogen and progesterone receptors, while only the 731Sa tumor also has glucocorticoid receptors. PRL release by the 731Sa tumor was stimulated...

P-Glycoproteins represent a family of drug efflux proteins that convey multidrug resistance to cells in which they are expressed. This phenomenon can lower the efficacy of drugs used in chemotherapy. The steroid progesterone has been shown to bind P-glycoproteins and inhibit their drug efflux. We report that the antiprogestin RU 486 can reverse multidrug resistance in cells overexpressing the m...

P-Glycoprotelns represent a family of drug efflux proteins that convey multidrug resistance to cells In which they are expressed. This phenome non can lower the efficacy of drugs used in chemotherapy. The steroid progesterone has been shown to bind P-glycoproteins and inhibit their drug emux. We report that the antiprogestin RU 486 can reverse multi drug resistance In cells overexpressing the m...

Aldosterone and glucocorticoids (GCs) stimulate Na(+) reabsorption in the collecting ducts by increasing the activity of the epithelial Na(+) channel (ENaC). Our laboratory has used Madin-Darby canine kidney-C7 cells to demonstrate that this effect is associated with an increase in alpha-ENaC gene transcription (Mick VE, Itani OA, Loftus RW, Husted RF, Schmidt TJ, and Thomas CP, Mol Endocrinol ...

BACKGROUND The use of sex steroids in oral contraception or hormonal replacement therapy is associated with an increased risk of cardiovascular thromboembolic complications. Although both the estrogen and the progestin components have been involved, the underlying mechanisms responsible are unclear. METHODS AND RESULTS This study examined whether sex steroids promote hemostasis indirectly by ...

We investigated the mechanisms underlying the protective action of glucocorticoids against indomethacin-induced gastric lesions. One-week adrenalectomized rats with or without corticosterone replacement (4 mg/kg sc) were administered indomethacin (25 mg/kg sc), and gastric secretion (acid, pepsin, and mucus), motility, microvascular permeability, and blood glucose levels were examined. Indometh...

When the human cell line NHIK 3025 was exposed to retinoic acid (1 nM; 10 microM), the cell cycle time was prolonged. Experiments using cells synchronized by mitotic selection showed that the retinoic acid induced growth delay was barely seen within the first cell cycle after exposure to 10 microM retinoic acid, whereas the next cell cycle durations were increased 30-60%. The effect was reversi...

The effect of dexamethasone on cytosolic pH (pHc) in resident mouse peritoneal macrophages was investigated using the fluorescent probe 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein tetra-acetoxymethyl ester (BCECF-AM). Dexamethasone was found to significantly lower pHc and this reduction of pHc evolved gradually with time, was near maximal at 10 nM dexamethasone, and could be prevented by th...

In poisoning operations, sublethal consumption of the toxin, can produce bait aversion. This decreases the effect of the poisoning and may create problems due to the presence of uneaten toxin in the environment. The use of new bait additives may prevent aversion development. Here I report the effects of two bait additives, corticosterone and mifepristone, in altering bait aversion development i...