Receptor tyrosine kinases-based autocrine loops largely contribute to activate the MAPK and PI3K/AKT pathways in melanoma. However, the molecular mechanisms involved in generating these autocrine loops are still largely unknown. In the present study, we examine the role of the transcription factor RUNX2 in the regulation of receptor tyrosine kinase (RTK) expression in melanoma. We have demonstr...

For many years, real-time DGPS and RTK correction data distribution have been providing GPS users a means to accomplish their tasks with high accuracy positioning in real-time. Dial-up systems over phone line or local area network (LAN) enable users to download data from base stations at remote locations. Radio modems provides wireless communication links between a base station and a rover to e...

In our study, we analyzed the combined standard uncertainty of water table slope assessment done using differential global positioning system (DGPS)-based measurements of water table elevation and distances between measurement locations. We compared and discussed uncertainties in water table slope assessments done in various hypothetical environments of lowland floodplains (water table slopes t...

We previously reported that hypotonic stress stimulated transepithelial Na(+) transport via a pathway dependent on protein tyrosine kinase (PTK; Niisato N, Van Driessche W, Liu M, Marunaka Y. J Membr Biol 175: 63-77, 2000). However, it is still unknown what type of PTK mediates this stimulation. In the present study, we investigated the role of receptor tyrosine kinase (RTK) in the hypotonic st...

Acceptable RTK GPS/GNSS performance is heavily dependent on a relativity unobstructed sky-view, where there are at least five satellites with good geometry available, and on the reliability of the wireless data link used for differential corrections. In “tough” GNSS applications where satellite occlusion is common, such as open cast mining, the RTK based technology often fails to deliver the re...

The key limitation of existing Real-Time Kinematic (RTK) systems is the service distances between reference stations and user receivers due to the impact of distance-dependent biases such as orbit error, and ionospheric and tropospheric signal delay. In current Network-RTK implementations, the inter-station distance is typically 70km to 90km. If coverage were to be extended to the whole Queensl...

CD44 has been postulated as a cell surface coreceptor for augmenting receptor tyrosine kinase (RTK) signaling. However, how exactly CD44 triggers RTK-dependent signaling remained largely unclear. Here we report an unexpected mechanism by which the CD44s splice isoform is internalized into endosomes to attenuate EGFR degradation. We identify a CD44s-interacting small GTPase, Rab7A, and show that...

The dorsoventral (DV) axis of the Drosophila embryo is patterned by a nuclear gradient of the Rel family transcription factor, Dorsal (Dl), that activates or represses numerous target genes in a region-specific manner. Here, we demonstrate that signaling by receptor tyrosine kinases (RTK) reduces nuclear levels and transcriptional activity of Dl, both at the poles and in the mid-body of the emb...

Metazoans use a handful of highly conserved signaling pathways to create a signaling backbone that governs development. How these few signals have such a versatile action likely depends upon the larger-scale network they form through integration, as exemplified by cross-talk between the Notch and receptor tyrosine kinase (RTK) pathways. We examined the transcriptional output of Notch-RTK cross-...

We have examined the role in patterning of quantitative variations of MAPK activity in signaling from the Drosophila Torso (Tor) receptor tyrosine kinase (RTK). Activation of Tor at the embryonic termini leads to differential expression of the genes tailless and huckebein. We demonstrate, using a series of mutations in the signal transducers Corkscrew/SHP-2 and D-Raf, that quantitative variatio...