نتایج جستجو برای: rs11614913

تعداد نتایج: 136  

2016
Zhi-Ming Dai Hua-Feng Kang Wang-Gang Zhang Hong-Bao Li Shu-Qun Zhang Xiao-Bin Ma Shuai Lin Meng Wang Yan-Jing Feng Kang Liu Xing-Han Liu Peng Xu Zhi-Jun Dai

MicroRNAs (miRNAs) play an important role as regulators of tumor suppressors and oncogenes in cancer-related processes. Single nucleotide polymorphisms (SNPs) in miRNAs have been shown to be relevant to various different cancers, including breast cancer (BC). The aim of this study was to estimate the associations between miRNA-related gene polymorphisms (miR-196a2, miR-499, and miR-608) and the...

Journal: :Anticancer research 2014
Soo Jung Lee Jong Won Seo Yee Soo Chae Jong Gwang Kim Byung Woog Kang Wan Wook Kim Jin Hyang Jung Ho Yong Park Ji Yun Jeong Ji-Young Park

BACKGROUND As microRNAs (miRNA) may play important roles in tumorigenesis by regulating the expression of proto-oncogenes or tumor suppressor genes, the present study analyzed single nucleotide polymorphisms (SNPs) located in miRNA and miRNA-binding sites of various genes and their impact on prognosis for 452 patients with early breast cancer. MATERIALS AND METHODS Three SNPs of miR-196a (rs3...

2014
Qiliu Peng Shan Li Xianjun Lao Zhiping Chen Ruolin Li Yan Deng Xue Qin Maissa El Said El Raziky.

MicroRNAs (miRNAs) are small non-coding RNA molecules that function as tumor suppressors or oncogenes. Single nucleotide polymorphisms (SNPs) located in the miRNAs influence the function of mature miRNAs and may contribute to cancer development. Studies investigating the association between miR-146a rs2910164 and miR-196a2 rs11614913 polymorphisms and hepatocellular carcinoma (HCC) risk reporte...

2015
Yu-Ming Niu Xin-Ya Du Ming-Yi Lu Qiong-Li Xu Jie Luo Ming Shen

Molecular epidemiological studies have showed a closer association between microRNA polymorphisms with and head and neck cancer (HNC) risk. But the results of these studies were inconsistent. We performed this meta-analysis to clarify the associations between microRNA polymorphisms and HNC risk. Four electronic databases (PubMed, Embase, CNKI, and Wanfang) were searched. Odds ratios (ORs) with ...

2017
Irma Karabegović Silvana Maas Carolina Medina-Gomez Maša Zrimšek Sjur Reppe Kaare M Gautvik André G Uitterlinden Fernando Rivadeneira Mohsen Ghanbari

MicroRNAs (miRNAs) are small non-coding RNA molecules that post-transcriptionally regulate the translation of messenger RNAs. Given the crucial role of miRNAs in gene expression, genetic variants within miRNA-related sequences may affect miRNA function and contribute to disease risk. Osteoporosis is characterized by reduced bone mass, and bone mineral density (BMD) is a major diagnostic proxy t...

اسلامی ثمرین, زهرا, طهماسب, محمد, قادری, عباس,

Breast cancer is the most common cancer worldwide and is the second leading cause of death in women after lung cancer. Micro RNAs (miRNAs) are among endogenous factors which are involved in many types of cancers, including breast cancer. Single nucleotide polymorphism (SNP) in the miRNAs, might change their biological activities such as their effects on oncogenes and tumor suppressor genes. The...

2015
Xiao-Xu Liu Meng Wang Dan Xu Jian-Hai Yang Hua-Feng Kang Xi-Jing Wang Shuai Lin Peng-Tao Yang Xing-Han Liu Zhi-Jun Dai

BACKGROUND The associations between polymorphisms in microRNAs and the susceptibility of colorectal cancer (CRC) were inconsistent in previous studies. This study aims to quantify the strength of the correlation between the four common polymorphisms among microRNAs (hsa-mir-146a rs2910164, hsa-mir-149 rs2292832, hsa-mir-196a2 rs11614913, and hsa-mir-499 rs3746444) and CRC risk. METHODS We sea...

2011
Haiyan Chu Meilin Wang Danni Shi Lan Ma Zhizhong Zhang Na Tong Xinying Huo Wei Wang Dewei Luo Yan Gao Zhengdong Zhang

BACKGROUND MicroRNAs (miRNAs) are a family of endogenous, small and noncoding RNAs that negatively regulate gene expression by suppressing translation or degrading mRNAs. Recently, many studies investigated the association between hsa-miR-196a2 rs11614913 polymorphism and cancer risk, which showed inconclusive results. METHODOLOGY/PRINCIPAL FINDINGS We conducted a meta-analysis of 15 studies ...

Journal: :Genetics and molecular research : GMR 2016
X M Pan X Xiao H J Qin Z Zhang Z H Li L B Gao J Jia

Colorectal cancer (CRC) is a multi-factorial disease, and genetic background may contribute to its etiology. Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) may be used as specific markers of predisposition for CRC diagnosis and prevention. In this review, we summarize and discuss recent publications evaluating the roles of miRNA SNPs in CRC. A meta-analysis was also carried out to...

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