objective(s):in the present study, we evaluated immunological and immunomodulatory properties of royal jelly (rj) in 2,4,6 trinitrobenzene sulfonic acid (tnbs)-induced colitis in rats. materials and methods: eighteen adult female wistar albino rats were divided into three groups of six animals each: a control group that received only saline solution, a tnbs-induced colitis group, and a tnbs-col...

Social caste determination in the honey bee is assumed to be determined by the dietary status of the young larvae and translated into physiological and epigenetic changes through nutrient-sensing pathways. We have employed Illumina/Solexa sequencing to examine the small RNA content in the bee larval food, and show that worker jelly is enriched in miRNA complexity and abundance relative to royal...

Prolonged excessive ingestion or consumption of alcohol eventually results in hepatic insufficiency; induces the aggravation of viral hepatitis and/or fatty liver. The long term ingestion of alcohol not only induces a decline in the immune function but also promotes the production of inflammatory cytokines by Kupffer cells activated by enterobacterial endotoxins. Royal Jelly has numerous functi...

BACKGROUND The aim of this study was to evaluate the effects of long and short term systemic usage of royal jelly on bone formation in the expanded maxillary suture in a rat model. MATERIAL AND METHODS Twenty eight Wistar albino rats were randomly divided into 4 equal groups: Control (C); Only Expansion (OE), Royal Jelly (RJ) group, Royal Jelly was given to rats by oral gavage only during the...

To assess different effects of royal Jelly in protecting the human endothelial cells from high glucose level, human umbilical vein endothelial cells were exposed to various concentrations of royal jelly, from 0.625 to 10 mg/ml, at the presence of 5 and 30 mM glucose contents over a course of 72 h. In addition to cell viability assessment by conventional MTT assay, we also analyzed the feature o...

Background. Royal jelly is a milky material secreted by the pharyngeal glands of young worker bees , which when fed as a sole nutrient to larvae causes the development of sexual mature queen bees. The unusual nature of this material has prompted different investigations into its biological/pharmacological/microbiological properties. As an part of the biological activity of royal jelly, an inves...

OBJECTIVE This study was conducted to evaluate the therapeutic effects of vaginal royal jelly and vaginal estrogen on quality of life and vaginal atrophy in postmenopausal women. METHODS This double-blind randomized controlled clinical trial was carried out at gynecology and obstetrics clinics of Hajar Hospital of Shahrekord University of Medical Sciences (Iran) from January 2013 to January 2...

Antibiotic-resistant bacteria continue to be of major health concern world-wide. Thus, it is of great interest to study the biological properties and determine active compounds in natural products likely to be used as new health remedies. Therefore, the main objective of this work is to test the antibacterial activity of royal jelly samples, defatted royal jelly samples and their ethyl ether ex...

Enzymatic hydrolysates were prepared from royal jelly using three enzymes (pepsin, trypsin, and papain), and their antioxidative properties were evaluated. The yield of these hydrolysates was very high, about 20-26% on a raw weight basis. In comparison with the antioxidative activities of water extract and alkaline extract of royal jelly, the antioxidative activities and scavenging activities a...