The Rho/ROCK pathway plays important roles in the modulation of the cytoskeletal integrity of cells, the synthesis of extracellular matrix components in the aqueous humor outflow tissue and the permeability of Schlemm's canal endothelial cells. The activation of the Rho/ROCK pathway results in trabecular meshwork (TM) contraction, and the inhibition of this pathway would provoke relaxation of T...

SINCE MYOCARDIAL INFARCT SIZE is the major contributor to the development of heart failure, interventions aiming to limit irreversible damage of ischemic myocardium are essential. In the clinical setting, reduction of myocardial oxygen demand and restoration of blood flow to the ischemic myocardium remain the primary targets to accomplish this goal, despite experimental evidence that reperfusio...

background and objectives: in the last few decades, losses of our cultural heritage due to biodeteriorationare beinghighly recognized. from museum objects to rock monuments, the microbial biodeterioration agents are found to be the most destructive. possibilities for proper preservative measure(s) are always more when it is only a monument, statue, museum article, or pre-historic art in any sma...

Laboratory tests were performed on 54 large size specimens of jointed rock mass under uniaxial loading conditions. Based on this experimental study, a methodology has been suggested to estimate strength and tangent modulus of rock masses through a weakness coefficient. The methodology involves mapping of joints in the field and laboratory testing of intact rock specimens to arrive at rock mass ...

Point load testing is used to determine rock strength indexes in geotechnical practice. The point load test apparatus and procedure enables economical testing of core or lump rock samples in either a field or laboratory setting. In order to estimate uniaxial compressive strength, index-to-strength conversion factors are used. These factors have been proposed by various researchers and are depen...

background: the concentrations of radionuclides like 226ra, 232th and 40k and the dose rate are measured in igneous and metamorphic rock formations in and around chickmagalur. a total of 236 samples from 13 different locations around study area were analyzed. materials and methods: the activity concentrations of the three radioactive elements were determined for mean period of 25000 s using hpg...

The stability analysis of rock slopes is a complex task for the geotechnical engineers due to the complex nature of the rock mass in a tropical climate that often has discontinuities in several forms, and consequently, in several types of slope failures. In this work, a rock mass classification scheme is followed in a tropical environment using the Rock Mass Rating (RMR) and Geological St...

Oilfield Review Summer 2011: 23, no. 2. Copyright © 2011 Schlumberger. For help in preparation of this article, thanks to Nicholas Drenzek, Cambridge, Massachusetts, USA. FLAIR is a mark of Schlumberger. Rock-Eval is a mark of the Institut Français du Pétrole. Rock-Eval 6 is a mark of Vinci Technologies SA. Every oil or gas play originates from source rock. The viability of each play—convention...

AIM To investigate the effects of mammalian homologue of Drosophila diaphanous-1(mDia1) and Rho-associated coiled-coil-containing protein kinase (ROCK) on the migration and adhesion of dental pulp cells (DPCs). METHODOLOGY Lysophosphatidic acid (LPA) was used to activate Rho signalling. mDia1 and ROCK were inhibited by short interfering RNA and the specific inhibitor, Y-27632, respectively. T...

Shroom (Shrm) proteins are essential regulators of cell shape and tissue morpho-logy during animal development that function by interacting directly with the coiled-coil region of Rho kinase (Rock). The Shrm-Rock interaction is sufficient to direct Rock subcellular localization and the subsequent assembly of contractile actomyosin networks in defined subcellular locales. However, it is unclear ...