Cyclooxygenases (COXs) are heme-containing sequence homodimers that utilize tyrosyl radical-based catalysis to oxygenate substrates. Tyrosyl radicals are formed from a single turnover of substrate in the peroxidase active site generating an oxy-ferryl porphyrin cation radical intermediate that subsequently gives rise to a Tyr-385 radical in the cyclooxygenase active site and a Tyr-504 radical n...

Abstract Aims Cardiovascular (CV) toxicities related to chemotherapy have been reported with increasing frequency. Thus, latest cardio-oncology guidelines focused on the importance of a baseline CV risk assessment before starting potentially cardiotoxic regimen, in order identify individuals at greater developing and prevent them. Despite these recommendations, there are still no validated syst...

The subclassification of glioblastoma (GBM) into clinically relevant subtypes using microRNA (miRNA)- and messenger RNA (mRNA)-based integrated analysis has been attempted. Because miRNAs regulate multiple gene-signaling pathways, understanding miRNA-mRNA interactions is a prerequisite for understanding glioma biology. However, such associations have not been thoroughly examined using high-thro...

Heat shock protein 90 (Hsp90) is an emerging therapeutic target of interest for the treatment of cancer. Its role in protein homeostasis and the selective chaperoning of key signaling proteins in cancer survival and proliferation pathways has made it an attractive target of small molecule therapeutic intervention. 17-Allylamino-17-demethoxygeldanamycin (17-AAG), the most studied agent directed ...

The financial crisis that swept across northern Europe in 1763 bears an uncanny resemblance to more recent episodes of financial market turbulence in particular, to the events of autumn 1998 when mature financial markets were caught in a severe liquidity crisis, culminating in the near collapse of Long-Term Capital Management. We highlight the salient features of the 1763 crisis, propose a styl...

In an experimental 2x2 coordination game with two strict equilibria we observe that, in contrast to equilibrium selection theory (Harsanyi and Selten 1988), only half of the subjects choose the strategy that relates to the payoffand risk-dominant equilibrium. We propose modified risk dominance as an explanation for the observed deviations from payoff and risk dominance. JEL classification: C72,...

This study aims to look at students' perceptions, problems and mastery Religious Secondary Schools (SMKA) Government Aided (SABK) in the state of Melaka on Arabic language, especially science balaghah identify thenproblems faced by students learning this knowledge. A total 30 form five out 504 were selected as respondents early SMKA SABK state. There are several identified that can interfere wi...

OBJECTIVE To explore the feasibility of digital photography for primary cervical cancer screening in a low-resource setting in El Salvador. METHODS Three independent examiners performed Pap test, visual inspection, digital camera assessment and colposcopy on each subject. RESULTS Lesions were detected in 99 of 504 patients (20%) by visual inspection, 72/504 (14%) by DART and 90/504 (18%) by...