Purpose: To investigate the effect of rhubarb on hyperoxia-induced lung injury in neonatal rats with bronchopulmonary dysplasia (BPD), and underlying mechanism.Methods: Sixty 4-day-old were assigned to air control, BPD, intervention groups, 20 each group. Immunoblotting was employed assay NF-κB expression. Levels malondialdehyde (MDA) SOD determined spectrophotometrically, while ELISA used meas...

To investigate the mechanism of action Rhubarb (Dahuang) in treatment colon cancer by network pharmacological method. TCMSP database was used to screen active components and targets Rhubarb, Genecards relevant cancer, Venny 2.1.0 software make intersection potential for were obtained.Cytoscape 3.7.2 STRING construct component-target related targets. The important obtained analyzing network, GO ...

The hepatotoxicity of some Chinese herbs has been a cause for concern in recent years. However, some herbs, such as rhubarb, have been documented as having both therapeutic and toxic effects on the liver, leading to the complex problem of distinguishing the benefits from the risks of using this herb. To comparatively analyze the dose-response relationship between rhubarb and hepatic health, we ...

the effects of ethanolic and aqueous extracts of rheum ribs l. (rr) of the family polygonaceae was studied on serum cholesterol concentration in rabbits. to induce hypercholesterolemia, 0.5 g/kg/day of pure cholesterol powder was given orally to each rabbit for two weeks then cholesterol was halved and each group of animals was treated with a different regimen for another two weeks. both the et...

In the course of our clinical studies of Kampo medicine (traditional Japanese medicines), we observed the pharmacokinetic interactions between two herbs. When Onpito (TJ-8117, Kampo medicine) containing licorice and rhubarb was administered orally to human subjects, we observed that the AUC(0-lim) and Cmax of glycyrrhetic acid (GA) in plasma were lower than those treated with other Kampo medici...

Tannins, a group of major active components of Chinese rhubarb and widely distributed in nature, have a significant antidiarrhoeal activity. Aquaporins (AQPs) 2 and 3 play important roles in regulating water transfer during diarrhoea. The present study aims to determine the effect of the total tannins extract of rhubarb on aquaporins (AQPs) 2 and 3 in diarrhoea mice and HT-29 cells both induced...

Due to the complexity of the chemical constitution of traditional Chinese medicines (TCMs), now there is a trend to establish methods, using multi-components analysis, for the effective quality control of TCMs. However, the limited availability of multiple reference substances hinders the wide popularization for routine quality control of TCMs. Using an easily available single component contain...

INTRODUCTION The official rhubarb species have frequently been investigated for their hydroxyanthraquinone components and associated pharmacological properties. However, other unofficial rhubarb species were rarely studied until polyhydroxystilbenes (PHS), which commonly occur in the unofficial rhubarb, revealed a range of potential bioactivities. Hence, there has been increasing interest in th...