Background One of the most important cause of severe neonatal hyperbilirubinemia is hemolysis including Rh incompatibility.  The aim of this study was to assess the rate of hyperbilirubinemia due to hemolysis in Rh positive neonates  born to Rh negative mothers. Methods In this retrospective study from March 1998 to February 2003, 60 icteric Rh positive newborns that were born to Rh negative m...

Toxoplasma gondii is one of the most prevalent parasitic infections in world. Rh, NED and Me49 are of the most prevalent clonal types of the parasite isolated till now. Differences in pathogenicity and virulence of different types have been investigated in different studies. No controlled study was performed to compare the ability of different types to initiate humoral immune response. We inves...

Human monoclonal anti-Rh(D) antibodies of known IgG isotype and Gm allotype were bound to erythrocytes and then used as the target IgG antigens for rheumatoid factors (RFs) in a direct haemagglutination test. When serum samples from patients with rheumatoid arthritis (RA) were tested for RF specificity towards these IgG monoclonal anti-D antibodies the incidence and titre of reactivity towards ...

CONTEXT/OBJECTIVE Hyperinsulinism with islet cell hyperplasia is a frequent complication, of unknown cause, in hemolytic disease of the newborn, occurring in Rh(D)-positive infants of Rh-isoimmunized Rh(D)-negative mothers, but not in infants with other hemolytic disorders. We investigated the possibility that trans-placentally acquired anti-D Ig is the cause of both conditions. DESIGN Monola...

DURING the past decade there has been a dramatic fall in the incidence and mortality from Rh haemolytic disease (Tovey 1976; Magee, lIarley, Campbell and McClure, 1969-78). This is due to two factors, firstly the appreciable fall in the number of Rh (D) negative women having babies, particularly if they had developed Rh antibodies previously; and secondly the routine administration of anti-D im...

This paper estimates the incremental cost-effectiveness of providing antenatal anti-D prophylaxis in varying dose sizes to either primigravidae or all Rh D negative women. It presents a model for calculating the net cost per 1000 'at risk' women based on the costs of anti-D prophylaxis and the future NHS costs avoided. Incremental cost-effectiveness is measured in terms of the net cost per Rh D...

Introduction While the use of elevated middle cerebral artery peak systolic velocity (MCA PSV) in assessing fetal anaemia is well known, its occurrence is uncommon due to the current practice of giving prophylactic doses of ultrafiltered Rh (D) immunoglobulin (anti-D) in Rh (D) negative women. In mothers who do not receive prophylaxis with Rh immunoglobulin, the overall risk of immunisation for...

The red cells of 63 members of 11 families were tested with (125)I-labeled anti-Rh(0)(D). Families with a history of hemolytic disease of the newborn due to fetomaternal Rh incompatibility were selected for study. In such families it was possible to determine the antibody binding to the Rh(0)(D) heterozygous red cells of the children and to compare within each family this value with the antibod...