PURPOSE To evaluate the reproducibility of peripapillary retinal nerve fiber layer (RNFL) thickness measurements in normal eyes and eyes with glaucoma using spectral domain optical coherence tomography (SDOCT). METHODS One eye of 79 normal and 72 glaucoma patients was analyzed. All patients underwent a complete ophthalmological examination, including visual acuity testing; intraocular pressur...

BACKGROUND AND OBJECTIVES Changes in ocular perfusion play an important role in the pathogenesis of ischemic optic neuropathy. Ocular perfusion pressure is equal to mean arterial pressure minus intraocular pressure. The aim of this study was to evaluate the changes in the intraocular pressure and the retinal nerve fiber layer thickness in patients undergoing spinal surgery in the prone position...

BACKGROUND Alzheimer's disease (AD) is the most common form of dementia and patients often have visual disorders. Mild cognitive impairment (MCI) is characterized by a memory deficit when compared with those of a similar age and education level which could indicate an earlier onset of AD. The aim of this study is to measure the changes of the retinal nerve fiber layer (RNFL) thickness of AD and...

Background: Modifications of the inner retinal layer is a frequent observation following pars plana vitectomy. Aim Work: To assess early changes thickness Retinal Nerve Fiber Layer after vitrectomy by ocular coherence tomography. Patients and Methods: This non-interventional observational study, in which 30 eyes patients underwent Examination Pars Plana Vitrectomy OCT. Cases were performed at O...

The Retinal Nerve Fiber Layer thickness is one of the main clinical parameter used to diagnose glaucoma eye disease. The thickness of the RNFL decreases as the intraocular pressure inside the eye increases. Decrease in RNFL thickness or damages to RNFL due to high intraocular pressure leads to Glaucoma. The present work provides a technique for the segmentation of Retinal Nerve Fiber Layer (RNF...

Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disorder that may have anterior visual pathway involvement. In this study, we compare the macular structure of patients with ALS to healthy controls, and examine correlations between macular sub-layer thickness measurements and pulmonary function tests and disease duration. ALS patients underwent optical coherence tomography (OC...

purpose: to compare peripapillary retinal nerve fiber layer (rnfl) thickness among multiple sclerosis (ms) patients with or without a history of optic neuritis (on) and a healthy control group. methods: in this retrospective case-control study, 59 ms patients were recruited from a neurology clinic of imam hossein hospital. of which, 36 patients had at least one episode of on and 23 others had n...

Glaucoma is an optic neuropathy that affects the ganglion cell complex in all its components: cell bodies, dendrites, and axons, the dendritic arbor being the first one damaged. This is the reason why the thickness of the ganglion cell and internal plexiform layers can be taken into account as an early predictor of the glaucomatous changes, along with the retinal nerve fiber layer (RNFL) thickn...

During early vertebrate eye development, a regulatory network of transcription factors regulates retinal cell differentiation and survival into adulthood. Among those factors, Krüppel-like factor 4 (KLF4) plays the dual role of maintaining the stem cell status of retinal progenitors cells and repressing the intrinsic axon regeneration ability in retinal ganglion cells (RGCs) after injury. This ...