Chronic pain due to osteoarthritis (OA) can lead to significant disruption of sleep and increased restlessness. Our objective was to assess whether naturally occurring canine OA is associated with nighttime restlessness and so has potential as a model of OA-associated sleep disturbance. The study was designed as a two-part prospective masked, placebo-controlled study using client-owned dogs (Pa...

To fuel their migratory endurance flights, most birds accumulate large quantities of fat prior to departure. It therefore seems logical that the decision depart on a flight depends stores, at least some extent; very small stores prohibit flight. However, studies linking migrants' estimated (or sometimes actual stores) departure likelihood or restlessness measured in captive (an accurate proxy f...

BACKGROUND Many older people with neuropsychiatric disorders such as Alzheimer's disease and frontotemporal dementia suffer from sleeping problems and often show nocturnal restlessness. Professionals and informal carers face considerable problems in solving these problems. Attempts to diminish these problems with medication in a safe and responsible manner have proven hardly effective or not ef...