in the present study the effect of the locally produced genetic adjuvant of ginea pig specific cpg-motif-containing oligodeoxynucleotide (cpg-odn) in an inactivated fmd virus vaccine was evaluated. boosting the ginea pigs with fmd vaccine along with cpg-odn adjuvant produced relatively higher ratio (5-fold) of fmdv-specific igg2a / igg1 than those vaccinated in the absence of cpg-odn. the neutr...

Background: Human colorectal cancer cells overexpress carcinoembryonic antigen (CEA). CEA is a glycoprotein which has shown to be a promising vaccine target for immunotherapy against colorectal cancer. Objective: To design a DNA vaccine harboring CEA antigen and evaluate its effect on inducing immunity against colorectal cancer cells in tumor bearing mice. <str...

Objective(s): Tuberculosis (TB) has still remained a global health issue. One third of the world's population is infected with tuberculosis and the current BCG vaccine has low efficiency; hence, it is necessary to develop a new vaccine against TB. The aim of the current study was to evaluate the efficiency of a novel DNA vaccine encoding Mtb32C-HBHA antigen in inducing specific immune responses...

in the present study, 360 male day-old broiler chicks were used to determine the effect of mixed livevaccines of newcastle disease (nd) and infectious bronchitis (ib) on serum and local antibody responses toib. chicks were randomly divided into 12 treatment groups of 3 replicates and reared for 40 days on floorpens. groups 1 to 5 received mixed nd and ib vaccine. groups 7 to 11 received ib vacc...

Objective(s): The results of studies on vaccine development for foot-and-mouth disease (FMD) virus show that the use of inactivated vaccines for FMD virus is not completely effective. Novel vaccinations based on immuno-dominant epitopes have been shown to induce immune responses. Furthermore, for safety of immunization, access to efficient adjuvants against FMD virus seems to be critical.Materi...

specific antibody deficiency lias been recognized as an immunodeficiency. in order to investigate an antipolysaccliaride antibody defect as a cause of rcccttrent infections, 30 children were studied. patients who had been identified to have a major immunodeficiency or structural abnormality or a disease known to cause infection were excluded. tliirty patints, aged i to 13.8 years (mean age, 5.8...

Objective(s): The porins A and B and also outer membrane vesicles (OMVs) of Neisseria meningitidis are used for vaccine purposes. In the present study, we aimed to design a new vaccine candidate based on a fusion of PorA of serogroups A and B of N. meningitidis admixed with OMV and evaluate it in an animal model.Materials and Methods: Af...

background: the major problem of dna vaccine is less immunogenicity of them verses other killed or live whole organism vaccines therefore adjuvants for use in this kind vaccines is very necessary. genetic adjuvants with bacterial sources are an appropriate approach to modulate immune responses to dna vaccines. listeria monocytogenes proteins such as listeriolysin o (llo) with cd4 and cd8 epitop...