Anderson J, Goplen C, Murray L, Seashore K, Soundarrajan M, Lokuta A, Strang K, Chesler N. Human respiratory mechanics demonstration model. Adv Physiol Educ 33: 53–59, 2009; doi:10.1152/ advan.90177.2008.—Respiratory mechanics is a difficult topic for instructors and students alike. Existing respiratory mechanics models are limited in their abilities to demonstrate any effects of rib cage movem...

INTRODUCTION Model-based methods can be used to characterise patient-specific condition and response to mechanical ventilation (MV) during treatment for acute respiratory distress syndrome (ARDS). Conventional metrics of respiratory mechanics are based on inspiration only, neglecting data from the expiration cycle. However, it is hypothesised that expiratory data can be used to determine an alt...

BACKGROUND Analysis of respiratory mechanics during mechanical ventilation (MV) is able to estimate resistive, elastic and inertial components of the working pressure of the respiratory system. Our aim was to discriminate the components of the working pressure of the respiratory system in infants on MV with severe bronchiolitis admitted to two PICU's. METHODS Infants younger than 1 year old w...

Citation: Botelho D, Leo BF, Massa C, Sarkar S, Tetley T, Chung KF, Chen S, Ryan MP, Porter A, Atochina-Vasserman EN, Zhang J, Schwander S and Gow AJ (2018) Exposure to Silver Nanospheres Leads to Altered Respiratory Mechanics and Delayed Immune Response in an in Vivo Murine Model. Front. Pharmacol. 9:213. doi: 10.3389/fphar.2018.00213 Exposure to Silver Nanospheres Leads to Altered Respiratory...

OBJECTIVE To evaluate changes in respiratory mechanics and tidal volume (V T) in wheezing infants in spontaneous ventilation after performing the technique known as the prolonged, slow expiratory (PSE) maneuver. METHODS We included infants with a history of recurrent wheezing and who had had no exacerbations in the previous 15 days. For the assessment of the pulmonary function, the infants we...

The Effect of Open Lung Ventilation on Respiratory Mechanics, Postoperative Organ Function, and Inflammatory Mediators in Coronary Artery Bypass Surgery

Introduction The Least Square Fitting (LSF) method is a statistical approach used for evaluating respiratory mechanics [1]. It allows measurement of respiratory mechanics continuously at the bedside, even in presence of flow limitation [23], without the need for constant inspiratory flow rate, endinspiratory hold and end-expiratory occlusion. These features allow the application of the LSF meth...

Injuries in trauma affect anatomical structures, indirectly affecting physiological systems through mechanical behavior and physical proximity. This paper describes the theory for and preliminary results from our approach to couple a three-dimensional (3-D) anatomical model of the chest with a physiological model of respiratory mechanics. In particular, we investigated behavior in quiet, normal...

Model-based mechanical ventilation (MV) can be used to characterise patient-specific condition and response to MV. This paper presents a novel method to visualise respiratory mechanics during MV of patients suffering from acute respiratory distress syndrome. The single compartment lung model is extended to monitor time-varying respiratory system elastance within each breathing cycle. Monitoring...

Introduction The amount of pathophysiological impairment in patients with acute respiratory distress syndrome (ARDS) is variable and applying the same ventilator regimen to every patient is questionable. Monitoring of respiratory mechanics for the lung and chest wall allows an individualization of ventilator settings with a potential benefit for the patient. A registry with a large sample size ...