This paper proposes LARS*, a location-aware recommender system that uses location-based ratings to produce recommendations. Traditional recommender systems do not consider spatial properties of users nor items; LARS*, on the other hand, supports a taxonomy of three novel classes of location-based ratings, namely, spatial ratings for non-spatial items, non-spatial ratings for spatial items, and ...

The endosomal sorting complexes required for transport (ESCRTs) constitute hetero-oligomeric machines that catalyze multiple topologically similar membrane-remodeling processes. Although ESCRT-III subunits polymerize into spirals, how individual ESCRT-III subunits are activated and assembled together into a membrane-deforming filament remains unknown. Here, we determine X-ray crystal structures...

Vps4 is a member of AAA+ ATPase (adenosine triphosphatase associated with diverse cellular activities) that operates as an oligomer to disassemble ESCRT-III (endosomal sorting complex required for transport III) filaments, thereby catalyzing the final step in multiple ESCRT-dependent membrane remodeling events. We used electron cryo-microscopy to visualize oligomers of a hydrolysis-deficient Vp...

climate is a complex system which is changing mainly due to the increase of greenhouse gases. because of the importance of climate change and the effects it can have on water resources, in recent years, this topic has been taken into consideration for different basins on earth. the objective of this study is to investigate the effects of climate change and forecasting meteorological variables o...

Low anterior resection syndrome (LARS) is increasingly recognized as a concern after low anterior resection for the treatment of rectal cancer. The lack of a precise definition outlining the symptoms and the time course that constitute LARS hinders ongoing research into the incidence, risk factors, pathophysiology, and treatment of this syndrome. This review will outline the current characteriz...

BACKGROUND Apathy is usually defined as reduced interest and participation in various activities. It is a frequent consequence of neurological and psychiatric disorders. Although various scoring methods have been proposed, there is a lack of validated, standardised instruments for detecting apathy and assessing its severity. OBJECTIVE To develop an apathy rating scale using a structured stand...

BACKGROUND We investigated very long-term bowel function after total mesorectal excision (TME) with or without preoperative short-course radiotherapy (PRT) for rectal cancer, the risk factors for bowel dysfunction, and the association of bowel dysfunction with health-related quality of life (HRQL). PATIENTS AND METHODS In the TME trial (1996-1999), 1530 Dutch patients with rectal cancer were ...

Objective: The aim of this study was to develop and validate a scoring system for bowel dysfunction after low anterior resection (LAR) for rectal cancer, on the basis of symptoms and impact on quality of life (QoL). Background: LAR for rectal cancer often results in severe bowel dysfunction (LAR syndrome [LARS]) with incontinence, urgency, and frequent bowel movements. Several studies have inve...