A family I.3 lipase from Pseudomonas sp. MIS38 (PML) contains 12 repeats of a nine-residue sequence motif in the C-terminal region. To elucidate the role of these repetitive sequences, mutant proteins PML5, PML4, PML1, and PML0, in which 7, 8, 11, and all 12 of the repetitive sequences are deleted, and PMLdelta19, in which 19 C-terminal residues are truncated, were constructed. Escherichia coli...

In the rehabilitation literature, fatigue is a common symptom of patients with any neurological impairment when defined as a subjective lack of physical and mental energy that interferes with usual activities. Some complaints may, however, arise from fatigability , an objective decline in strength as routine use of muscle groups proceeds. By this refined definition of fatigue, exercise or susta...

Introduction Autism is a neurodevelopmental disorder characterised by impairments in social communication and interaction; an unusually intense, circumscribed interest or restricted, repetitive and stereotyped patterns of behaviour, interests and activities (ICD-10). However the underlying neuropathology of Autism remains controversial. Here we present evidence of bilateral medial temporal lobe...

BACKGROUND It has previously been shown that conditioning activities consisting of repetitive hops have the potential to induce better drop jump (DJ) performance in recreationally active individuals. In the present pilot study, we investigated whether repetitive conditioning hops can also increase reactive jump and sprint performance in sprint-trained elite athletes competing at an internationa...

Dear Sir, According to the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM‐5), autism spectrum disorders (ASD) are neurodevelopmental disorders whose core clinical features are persisting deficits in social communication and interaction as well as restricted, repetitive behaviors, interests, and activities.[1] Today, there are no biomarkers for ASD, whose diagnosis is sti...