Current MPI (Message Passing Interface) communication libraries require larger memories in proportion of the number of processes, and can not be used for exa-scale systems. This paper proposes a global memory based communication design to reduce memory usage for exascale communication. To realize exa-scale communication, we propose true global memory based communication primitives called Advanc...

Memory-intensive applications suffer large performance loss when their working sets do not fully fit in memory. Yet, they cannot leverage otherwise unused remote memory when paging out to disks even in the presence of large imbalance in memory utilizations across a cluster. Existing proposals for memory disaggregation call for new architectures, new hardware designs, and/or new programming mode...

In addicts, associative memories related to the rewarding effects of drugs of abuse can evoke powerful craving and drug seeking urges, but effective treatment to suppress these memories is not available. Detailed insight into the neural circuitry that mediates expression of drug-associated memory is therefore of crucial importance. Substantial evidence from rodent models of addictive behavior p...

Cache-only memory access (COMA) multiprocessors support scalable coherent shared memory with a uniform memory access programming model. The local portion of shared memory associated with a processor is organized as a cache. This cache-based organization of memory results in long remote memory access latencies. Latency-hiding mechanisms can reduce eeective remote memory access latency by making ...

Although formation and stabilization of long-lasting associative memories are thought to require time-dependent coordinated hippocampal-cortical interactions, the underlying mechanisms remain unclear. Here, we present evidence that neurons in the rat cortex must undergo a "tagging process" upon encoding to ensure the progressive hippocampal-driven rewiring of cortical networks that support remo...

Several studies have shown that the isolated retrieval of a consolidated fear memory can induce a labile phase, during which extinction training can prevent the reinstatement, a form of relapse in which fear response to a fear-provoking context returns when a mild shock is presented. However, fear memory retrieval may also have another opposing result: the enhancement of fear memory. This impli...

Multithreading is very effective at tolerating the latency of remote memory accesses in distributed memory parallel computers, but does nothing to reduce the number or cost of those memory accesses. Compiler techniques and runtime approaches, such as caching remote memory accesses and prefetching, are often used to reduce the number of remote memory accesses. Another approach to reduce the numb...