Numerous compounds including pharmaceutical agents, herbicides, and plasticizers have been identitied as peroxisome proliferators in rodents (Each0 and Feller, 1991; Lake et al., 1984; Lalwani et al., 1983; Moody and Reddy, 1978). The hepatic effects of these compounds include increases in the number and size of hepatic peroxisomes, hepatomegaly, hepatocellular hypertrophy, and increased rates ...