It is desired to make the Economic Plantwide Control design procedure proposed by Skogestad (2000, 2004, 2012) available for engineers without deep knowledge of process control or optimization. The integration of the use of commercial process simulators to obtain the process model could be a useful tool for the automation of the economic plantwide design procedure. However, process simulators a...

This paper focuses on the dynamic behavior of process networks consisting of a reactor with highly exothermic chemical reactions that occur with different rates, connected via a high material recycle stream to an external heat exchanger. By employing singular perturbation arguments, we show that the dynamics of the considered process networks typically exhibits three distinct time scales, the f...

This paper deals with the vibrational control of a recycled bioprocess, which takes place into a Continuous Stirred Tank Bioreactor (CSTB). The classical control techniques for bioreactors necessitate measurements of states and/or disturbances. However, the bioprocesses are systems that require costly and difficult on-line implementation for sensors. Vibrational control is a non-classical open-...

This paper briefl y presents two concepts of “RE” (1) re-empowering individuals using personal mobile technology reconstructed as measurement instruments and (2) re-cycle as a design constraint for extending a product’s usable lifetime. In the fi rst example we demonstrate the integration of simple low-cost, low-power air quality sensors attached to a mobile phone. In the re-cycle case, we demo...

M ultivesicular bodies (MVBs) are specialized endosomes that promote the degradation of membrane proteins by delivering them to lysosomes. This process is regulated by a series of endosomal sorting complexes required for transport (ESCRTs) (1). The ESCRT-0,-I, and-II complexes sequester ubiquitinated membrane proteins and recruit the ESCRT-III complex to drive the invagination and release of ca...

We have examined the effect of complete cell recycle on the production of cholera toxin (CT) by Vibrio cholerae and CT-like toxin by Vibrio mimicus in continuous culture fermentations. Complete cell recycle was obtained by filtering culture fluids through Amicon hollow fibers with an exclusion limit of 100,000 daltons (H1P100-20) and returning the concentrated cell slurry to the fermentor. A si...