Background: Epilepsy is a chronic disease characterized by the occurrence of recurrent non provoked epileptic seizures. This condition affects quality life those affected as well their caregivers’ not only itself but also because comorbidity. It requires daily care and continuous use anti seizure medication at specific times day.

Background: Febrile seizure (FS) is one of the most common neurologic disorders in children. Electrolyte imbalance especially hyponatremia may have an important role triggering febrile seizure. The measure serum electrolytes will be useful predicting further seizures. This study aimed to investigate effect relative on risk recurrent Methods: prospective was performed 115 children (6-60 months) ...

Epileptic seizures are characterized by periods of recurrent, highly synchronized activity that spontaneously terminates, followed by postictal state when neuronal activity is generally depressed. The mechanisms for spontaneous seizure termination and postictal depression remain poorly understood. Using a realistic computational model, we demonstrate that termination of seizure and postictal de...

Seizures are one of the commonest neurological symptoms seen in children. Recurrent seizures could ensue from epilepsy, febrile seizures, provoked seizures, drug inefficacy or with, or due to unknown or systemic illnesses [1]. A breakthrough seizure is an epileptic seizure that occurs, despite the use of anticonvulsants that have otherwise successfully prevented seizures in the patient. Breakth...

BACKGROUND Epileptic seizures account for 1%-2% of all admissions of patients to the emergency department (ED). The present study aimed to determine whether venous blood pH, bicarbonate, base excess, and lactate levels taken within 1 hour of the last seizure episode help to determine seizure recurrence in emergency departments. METHODS A cross-sectional study was conducted in the emergency de...

Astrocytes modulate neuronal activity, synaptic transmission, and behavior by releasing chemical transmitters in a process termed gliotransmission. Whether this process impacts epilepsy in vivo is not known. We show that genetic impairment of transmitter release from astrocytes by the expression of a glial dominant-negative SNARE domain in mice reduced epileptiform activity in situ, delayed sei...

Hyperkalemia is a severe life-threatening electrolyte disorder that commonly affects the cardiac conductivity and contractility. Ascending paralysis affecting the extremities with focal neurological deficit as well as quadriparesis and a seizure associated with hyperkalemia has been reported in the literature. Here, we describe a case of isolated recurrent lower extremity paralysis and an episo...

PURPOSE In this study we evaluated the effects of undernourishment and seizures on memory and spatial learning in a model of developing brain. EXPERIMENTAL PROCEDURES Male Wistar rat pups were allocated to one of six experimental groups: nourished control (NC), nourished recurrent seizures (NRS), nourished status epilepticus (NSE), undernourished control (UC), undernourished recurrent seizure...

BACKGROUND Seizure is a common complication after stroke (termed "post-stroke seizure," PSS). Although many studies have assessed outcomes and risk factors of PSS, no reliable predictors are currently available to determine PSS recurrence. We compared baseline clinical characteristics and post-stroke treatment regimens between recurrent and non-recurrent PSS patients to identify factors predict...