Specific idiotypie can be induced in randomly chosen rabbits by preimmunization with anti-idiotypic antibodies (Ab2). Rabbits that synthesize anti-anti-idiotypic antibodies (Ab3) when injected with antigen produce antibodies that display idiotypic specificities that are also found on the starting idiotype. When female rabbits actively producing Ab3 are crossed with naive males, a significant pr...

A critical discussion of data on the possible role of IgG3 cryoglobulins, cross-reactive anti-DNA antibodies and anti-DNA idiotypes in the pathogenesis of lupus nephritis is included. A further possibility involving cationic nuclear autoantigens is presented in detail. Histone was employed as a model antigen, representative of this group. Histones were shown to have high affinity for the rat GB...

An idiotype is an antigenic determinant unique (private) to a given antibody molecule and is associated with the antigen combining site of the antibody. Crossreactive idiotypes are shared antigenic determinants between antibodies of different antigenic specificities in one individual or among antibodies against the same antigen in different individuals. Monoclonal IgM rheumatoid factors were th...

Even though it has been relatively easy to demonstrate the immunogenicity of azobenzenearsonate compounds in the guinea pig (1-5) and the rat (6), the mouse has distinct advantages in terms of ease of T-cell identification and the characterization of idiotypic markers associated with anti-azobenzenearsonate (ABA) t specificity. A major cross-reactive idiotype (CRI) found on 20-70% of the anti-A...

In spite of their many facets, the phenomena of autoimmunity and immunodeficiency seem to be related to each other through the subtle links connecting retroviral mutation and action to immune response and adaptation. In a previous work, we introduced a network model of how a set of interrelated genotypes (called a quasispecies, in the stationary state) and a set of interrelated idiotypes (an id...

of monoclonal human IgRF autoantibodies. J Exp Med 1984;160:893-904. 44. Fong S, Chen PP, Gilbertson JA, el al. Expression of three cross reactive idiotypes on rheumatoid factor autoantibodies from patients with autoimmune diseases and seropositive adults. J Immunol 1986;137: 122-8. 45. Chen PP, Albrandt K, Orida NK, etal. Genetic basis for the cross-reactive idiotypes on the light chains of hu...