Pathological mechanisms underlying diabetic retinopathy are still not completely understood. Increased understanding of potential cellular pathways responsive to hyperglycemia is essential to develop novel therapeutic strategies for diabetic retinopathy. A growing body of evidence shows that microRNA (miRNA) play important roles in pathological mechanisms involved in diabetic retinopathy, as we...

Evaluating the practice of ethical review by Research Ethics Committees (REC) could help protect the interests of human participants and promote scientific progress. To facilitate such evaluations, we conducted an ethnographic study of how an REC reviews research proposals during its meetings. We observed 13 meetings of a Dutch REC and studied REC documents. We coded this material inductively a...

Meiotic crossovers are not randomly distributed along the chromosome. In Caenorhabditis elegans the central portions of the autosomes have relatively few crossovers compared to the flanking regions. We have measured the frequency of crossing over for several intervals across chromosome I in strains mutant for rec-1. The chromosome is approximately 50 map units in both wild-type and rec-1 homozy...

In a comprehensive LMDI-STIRPAT-ARDL framework, this research investigates the residential electricity consumption (REC)-income nexus in Morocco for period 1990 to 2018. The logarithmic mean Divisia index (LMDI) results show that economic activity and intensity are leading drivers of Morocco’s REC, followed by population structure. And then, LMDI analysis was combined with stochastic impacts re...

BACKGROUND Previous studies have shown that preloading an antagonist muscle may increase the acute agonist neuromuscular performance. In addition, studies have suggested that very short-term resistance exercise (RE) programs may also be useful to increase strength and muscular performance. OBJECTIVES To evaluate the effects of three days of RE using a reciprocal action method on the muscular ...

In newborn rats the levels of nerve growth factor (NGF) mRNA (mRNANGF) and NGF receptor mRNA (mRNA(rec)) in the sciatic nerve were 10 and 120 times higher, respectively, than in adult animals. mRNA(rec) levels decreased steadily from birth, approaching adult levels by the third postnatal week, whereas mRNANGF levels decreased only after the first postnatal week, although also reaching adult lev...

OBJECTIVE To detect the presence of antibodies to the proacrosin/acrosin system and to evaluate their effect on the sperm acrosomal protein activities in women consulting for infertility. DESIGN Retrospective study. SETTING Basic research laboratory. PATIENT(S) Recombinant proteins derived from human proacrosin (Rec-40, Rec-30, Rec-20, Rec-10) and recombinant human zona pellucida (ZP) gly...

Many problems in interprocedural program analysis can be modeled as the context-free language (CFL) reachability problem on graphs and solved cubic time. Despite years of efforts, there are no known truly sub-cubic algorithms for this problem. We study related certification task: given an instance CFL reachability, small efficiently checkable certificates existence non-existence a path? show th...