Periodic lateralized epileptiform discharges (PLEDs) are a well defined electroencephalographic entity but whether PLEDs represent an ictal condition or not remains debated. Much work has been done using electroencephalography (EEG) but new approaches using cerebral perfusion imaging may give more information about this question. We aimed to evaluate if PLEDs were associated with high regional ...

OBJECTIVES Although many previous reports have described age-related changes in regional cerebral blood flow (rCBF), none has used 3D stereotactic surface projection (3D-SSP) analysis, which is able to detect subtle and significant changes in rCBF. METHODS The subjects were 31 healthy volunteers (16 men and 15 women; 50-79 years of age) without abnormal MR imaging and MR angiographic findings...

Regional cerebral blood flow (rCBF)was assessed with single photon emission computed tomograhy (SPECT), I-N-isopropyl-iodoamphetamine ( I-IMP), and the Table-Look-Up method in 51 children (27 boys,24 girls)considered neurologically normal and aged 1 month to 15 years (mean age,4 years 1 month;SD 3 years 11 months)divided into seven age groups. The rCBF was measured in cortical regions, the cere...

BACKGROUND AND PURPOSE Widespread pain sensitivity in patients with FM suggests a CNS processing problem. The purpose of this study was to assess alterations in perfusion as measured by DSC in a number of brain regions implicated in pain processing between patients with FM and healthy controls. MATERIALS AND METHODS Twenty-one patients with FM and 27 healthy controls underwent conventional MR...

PURPOSE We compared the regional cerebral blood flow (rCBF) obtained by pulsed continuous arterial spin labeling (pCASL) and iodine-123-N-isopropyl-p-iodoamphetamine (IMP) single photon emission computed tomography (SPECT) using 3-dimensional stereotactic region-of-interest (ROI) software for automated definition of ROIs in anatomic regions of the brain. METHODS Thirteen patients with cerebro...

In eight patients undergoing carotid endarterectomy, the mean velocity and an index of pulse amplitude in the middle cerebral artery were monitored continuously by transcranial doppler ultrasound. rCBF was measured by intracarotid injection of 133 Xenon shortly before and at the time of the carotid artery occlusion, and again a few minutes after carotid flow was reestablished. Comparison of the...

To evaluate the diagnostic importance of event-related potential P300, the correlation between P300 and regional cerebral blood flow (rCBF) was investigated in various brain regions in patients with multiple cerebral infarction (16 cases), chronic alcoholism (11 cases) and Alzheimer's disease (5 cases) and in seven healthy people. Cognitive function was also evaluated by mini-mental state exami...

For the study of cerebral hemodynamics in patients with multiple occlusive or stenotic lesions of the internal carotid artery (lCA) and vertebral/basilar artery (VA/BA), six male patients (mean aged 62.5 years) were examined by regional cerebral blood flow(rCBF; Fg: intravenous bolus injection of Xe 133). The highest rCBF(73.3 ± l6.l(SD)m2/100g/min) was observed in two patients with stenosis of...

UNLABELLED We tested the hypothesis that educational level influences regional cerebral blood flow (rCBF) in Alzheimer's disease (AD) patients. METHODS The severity of AD was measured with the Cognitive Ability Screening Instrument (age and education adjusted). rCBF was assessed using (99m)Tc-hexamethylpropyleneamine oxime brain SPECT; differences in rCBF between groups with different educati...

Deep brain stimulation of the subthalamic nucleus (STN DBS) improves motor symptoms in idiopathic Parkinson's disease, yet the mechanism of action remains unclear. Previous studies indicate that STN DBS increases regional cerebral blood flow (rCBF) in immediate downstream targets but does not reveal which brain regions may have functional changes associated with improved motor manifestations. W...