chicken chemokine can help heal wounds by inducing fibroblasts to become myofibroblasts, according to results reported by Feugate et al. on page 161. The contractile myofibroblasts help close the wound by pulling together the necessary cells and matrix. Chemokines are better known for their activities in the immune system, but increased production of chicken chemotactic and angiogenic factor (c...

Polyomavirus T antigens share a common N-terminal sequence that comprises a DnaJ domain. DnaJ domains activate DnaK molecular chaperones. The functions of J domains have primarily been tested by mutation of their conserved HPD residues. Here, we report detailed mutagenesis of the polyomavirus J domain in both large T (63 mutants) and middle T (51 mutants) backgrounds. As expected, some J mutant...

A prior retrospective study suggested that the level of retinoblastoma protein (RB) expression was prognostic for survival in acute myelogenous leukemia (AML). Individuals with no/low RB protein expression were considered to have loss of RB function, and those with maximally phosphorylated (maxphos) RB were also felt to have nonfunctional RB. To confirm this, we prospectively investigated wheth...

The nanostructures synthesized using the green chemistry method have recently attracted attention of scientists due to their significance in many scientific domains. This work provides an overview biosynthesis zinc oxide (ZnO) nanosheets (NSs) Phyllanthus emblica plant (PEP) extract. X-ray diffraction analysis (XRD), photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and Four...

Repetition blindness (RB) refers to the impairment in reporting two identical targets within a rapid serial visual presentation stream. While numerous studies have demonstrated RB for words and picture of objects, very few studies have examined RB for faces. This study extended this research by examining RB when the two faces were complete repeats (same emotion and identity), identity repeats (...

The retinoblastoma susceptibility gene (Rb) participates in controlling the G1/S-phase transition, presumably by binding and inactivating E2F transcription activator family members. Mouse embryonic fibroblasts (MEFs) with no, one, or two inactivated Rb genes were used to determine the specific contributions of Rb protein to cell cycle progression and gene expression. MEFs lacking both Rb allele...

The mammalian SWI-SNF complex is a chromatin-remodelling machinery involved in the modulation of gene expression. Its activity relies on two closely related ATPases known as brm/SNF2alpha and BRG-1/SNF2beta. These two proteins can cooperate with nuclear receptors for transcriptional activation. In addition, they are involved in the control of cell proliferation, most probably by facilitating p1...

BACKGROUND The retinoblastoma (Rb) tumor suppressor protein can function as a DNA replication inhibitor as well as a transcription factor. Regulation of DNA replication may occur through interaction of Rb with the origin recognition complex (ORC). PRINCIPAL FINDINGS We characterized the interaction of Drosophila Rb, Rbf1, with ORC. Using expression of proteins in Drosophila S2 cells, we found...